Vitamin D and aging.
Vitamin D and aging.
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DOI：
10.1016/j.ecl.2013.02.004
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发表时间：
2013-06
影响因子：
4.5
通讯作者：
Gallagher, J. Christopher
中科院分区：
文献类型：
--
作者：
Gallagher, J. Christopher
衰老影响维生素D的活性形式1，25-二羟基维生素D（1，25 [OH]2D;骨化三醇）的形成。1，25（OH）2D的产生减少了50%，这是年龄相关的肾功能下降的结果，尽管血清1，25（OH）2D水平部分地通过继发性甲状旁腺功能亢进维持。衰老也会导致钙吸收减少，这比1，25（OH）2D减少早10至15年。由于1，25（OH）2D依赖于底物维生素D的充足供应，因此维生素D缺乏的发展导致1，25（OH）2D的形成进一步减少。代谢物25 OHD的测量提供了最广泛使用的维生素D缺乏症的评估。血清25 OHD水平低于10 ng/mL（25 nmol/L）表示维生素D缺乏，并导致血清1，25（OH）2D减少。维生素D缺乏症在北美并不常见，可能是因为乳制品和其他食物补充了维生素D。在4月至9月期间，阳光暴露使血清25 OHD水平增加约10 ng/mL，导致冬季血清25 OHD低水平约3至4个月，在北方纬度地区（如加拿大）还有2个月的低水平，在南方各州则少2个月。冬季补充维生素D可以预防维生素D缺乏症。维生素D不足已被医学研究所定义为血清25 OHD水平低于20 ng/mL（和>10 ng/mL）。血清25 OHD水平低于20 ng/mL与骨折率增加、骨丢失率增加和治疗相关。虽然其他疾病与血清25 OHD水平低有关，但病因作用的证据尚未确定。每天用800 IU维生素D治疗老年人将使血清25 OHD水平提高到20 ng/mL以上，并减少骨折;这对机构化的人特别重要。
Aging affects the formation of 1,25-dihydroxyvitamin D (1,25[OH]2D; calcitriol), the active form of vitamin D. Production of 1,25(OH)2D is reduced by 50% as a result of an age-related decline in renal function, although serum 1,25(OH)2D levels are maintained in part by secondary hyperparathyroidism. Aging also causes a decrease in calcium absorption that precedes the decrease in 1,25(OH)2D by 10 to 15 years. Because 1,25(OH)2D is dependent on an adequate supply of the substrate vitamin D, the development of vitamin D deficiency leads to further reduction in the formation of 1,25(OH)2D. Measurement of the metabolite 25OHD provides the most widely used assessment of vitamin D deficiency. A serum 25OHD level lower than 10 ng/mL (25 nmol/L) represents vitamin D deficiency and leads to a reduction in serum 1,25(OH)2D. Vitamin D deficiency, is uncommon in North America, probably because of supplementation of dairy products and other foods with vitamin D. Sunlight exposure increases serum 25OHD levels by about 10 ng/mL during the months of April through September, resulting in low serum 25OHD for about 3 to 4 months in winter, with 2 additional months of low levels in more northern latitudes, such as Canada, and 2 fewer months in the southern states. Vitamin D supplementation in the winter can prevent vitamin D deficiency. Vitamin D insufficiency has been defined by the Institute of Medicine as a serum 25OHD level lower than 20 ng/mL (and >10 ng/mL). A serum 25OHD level lower than 20 ng/mL is associated with an increased fracture rate and increased rate of bone loss and treatment. Although other diseases have been associated with low serum 25OHD levels, the evidence for a causative role has not yet been established. Treatment of elderly people with vitamin D 800 IU daily will increase serum 25OHD levels to higher than 20 ng/mL and reduce fractures; this is particularly important in institutionalized people.
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影响因子：
5.8
作者：
Gallagher, J. Christopher;Yalamanchili, Vinod;Smith, Lynette M.
通讯作者：
Smith, Lynette M.
影响因子：
2.4
作者：
Bruyere, Olivier;Decock, Caroline;Reginster, Jean-Yves
通讯作者：
Reginster, Jean-Yves
DOI：
10.1016/j.jsbmb.2006.12.082
发表时间：
2007-03-01
影响因子：
4.1
作者：
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通讯作者：
Smith, Lynette
影响因子：
5.8
作者：
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通讯作者：
Orwoll, Eric S.
影响因子：
6.2
作者：
Cauley, Jane A.;Danielson, Michelle E.;Boudreau, Robert;Barbour, Kamil E.;Horwitz, Mara J.;Bauer, Douglas C.;Ensrud, Kristine E.;Manson, JoAnn E.;Wactawski-Wende, Jean;Shikany, James M.;Jackson, Rebecca D.
通讯作者：
Jackson, Rebecca D.