Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors.
Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors.
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创建定制的细胞内生态位：军团菌 IV 型分泌系统效应器颠覆宿主细胞信号传导。
DOI：
10.1139/cjm-2015-0166
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发表时间：
2015
影响因子：
2.8
通讯作者：
So EC
中科院分区：
文献类型：
--
作者：
So EC
嗜肺军团菌是革兰氏阴性兼性胞内病原体，可感染环境中多种不同的原生动物，也可感染吸入污染气溶胶的人肺泡巨噬细胞。在宿主体内，它创造了一个定义明确的独特区室，称为含军团菌空泡（LCV），用于生存和复制。为了建立LCV，嗜肺军团菌使用其Dot/Icm IV型分泌系统（T4 SS）将超过300种效应蛋白易位到宿主细胞中。尽管在过去的几年里，这些效应子破坏了许多细胞过程，并允许军团菌控制宿主细胞囊泡的运输、转录和翻译，但绝大多数效应子的确切功能仍然未知。这部分是由于效应子之间的高功能冗余，这使得传统的遗传方法来阐明其作用无效。在这里，我们回顾了有关军团菌T4 SS效应子的当前知识，强调了悬而未决的问题，并讨论了有望促进未来T4 SS效应子功能表征的新方法。
The Gram-negative facultative intracellular pathogenLegionella pneumophilainfects a wide range of different protozoa in the environment and also human alveolar macrophages upon inhalation of contaminated aerosols. Inside its hosts, it creates a defined and unique compartment, termed theLegionella-containing vacuole (LCV), for survival and replication. To establish the LCV,L.pneumophilauses its Dot/Icm type IV secretion system (T4SS) to translocate more than 300 effector proteins into the host cell. Although it has become apparent in the past years that these effectors subvert a multitude of cellular processes and allowLegionellato take control of host cell vesicle trafficking, transcription, and translation, the exact function of the vast majority of effectors still remains unknown. This is partly due to high functional redundancy among the effectors, which renders conventional genetic approaches to elucidate their role ineffective. Here, we review the current knowledge aboutLegionellaT4SS effectors, highlight open questions, and discuss new methods that promise to facilitate the characterization of T4SS effector functions in the future.
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