Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study.
Risk factors for default from tuberculosis treatment in HIV-infected individuals in the state of Pernambuco, Brazil: a prospective cohort study.
复制标题
DOI：
10.1186/1471-2334-11-351
复制
发表时间：
2011-12-16
影响因子：
3.7
通讯作者：
Ximenes RA
中科院分区：
文献类型：
--
作者：
Maruza M;Albuquerque MF;Coimbra I;Moura LV;Montarroyos UR;Miranda Filho DB;Lacerda HR;Rodrigues LC;Ximenes RA
伴随着人类免疫缺陷病毒(HIV)感染和结核病(TB)的治疗，对提供者和患者的治疗依从性提出了一系列挑战。我们进行了这项研究，以确定艾滋病毒携带者因结核病治疗而违约的风险因素。我们在巴西伯南布哥进行了一项队列研究，每月监测艾滋病毒/结核病合并感染者，直到结核病治疗完成或违约。Logistic回归用于计算原始和调整后的优势比、95%可信区间和P值。从2310名艾滋病毒受试者中，选择了390名(16.9%)在确诊为结核病后开始治疗的人，并对273名完成或未完成结核病治疗的人的数据进行了分析。违约率为21.7%，确定了以下危险因素：男性、吸烟和CD4T细胞计数低于200个/mm3。年龄超过29岁，完成或未完成中学或大学教育，以及使用高效抗逆转录病毒疗法(HAART)被确定为影响结果的保护性因素。结果表明，有必要采取更具体的行动，旨在减少男性、低教育程度的年轻人、吸烟者和CD4T细胞计数为200个/mm3的人因结核病治疗而违约的情况。在接受HAART的患者中，违约发生的可能性较小，这强化了在结核病患者中早期启动HAART的策略。
Concomitant treatment of Human Immunodeficiency Virus (HIV) infection and tuberculosis (TB) presents a series of challenges for treatment compliance for both providers and patients. We carried out this study to identify risk factors for default from TB treatment in people living with HIV. We conducted a cohort study to monitor HIV/TB co-infected subjects in Pernambuco, Brazil, on a monthly basis, until completion or default of treatment for TB. Logistic regression was used to calculate crude and adjusted odds ratios, 95% confidence intervals and P-values. From a cohort of 2310 HIV subjects, 390 individuals (16.9%) who had started treatment after a diagnosis of TB were selected, and data on 273 individuals who completed or defaulted on treatment for TB were analyzed. The default rate was 21.7% and the following risk factors were identified: male gender, smoking and CD4 T-cell count less than 200 cells/mm3. Age over 29 years, complete or incomplete secondary or university education and the use of highly active antiretroviral therapy (HAART) were identified as protective factors for the outcome. The results point to the need for more specific actions, aiming to reduce the default from TB treatment in males, younger adults with low education, smokers and people with CD4 T-cell counts < 200 cells/mm3. Default was less likely to occur in patients under HAART, reinforcing the strategy of early initiation of HAART in individuals with TB.
登录
查看更多内容
DOI：
10.1056/nejmoa0905848
发表时间：
2010-02-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Abdool Karim SS;Naidoo K;Grobler A;Padayatchi N;Baxter C;Gray A;Gengiah T;Nair G;Bamber S;Singh A;Khan M;Pienaar J;El-Sadr W;Friedland G;Abdool Karim Q
通讯作者：
Abdool Karim Q
影响因子：
5.7
作者：
Meintjes, Graeme;Rabie, Helena;Cotton, Mark F.
通讯作者：
Cotton, Mark F.
影响因子：
2.7
作者：
Maruza, Magda;Ximenes, Ricardo Arraes de Alencar;Lacerda, Heloísa Ramos
通讯作者：
Lacerda, Heloísa Ramos
DOI：
10.1590/s0102-311x2008001600003
发表时间：
2008-01-01
期刊：
Cadernos de Saúde Pública
影响因子：
--
作者：
Brasil, Pedro Emmanuel Alvarenga Americano do;Braga, José Ueleres
通讯作者：
Braga, José Ueleres
影响因子：
2.8
作者：
Lima, M. B. de;Mello, D. A.;da Silva, W. C.
通讯作者：
da Silva, W. C.