Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague-Dawley rat.
Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague-Dawley rat.
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DOI：
10.1016/j.physbeh.2014.01.018
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发表时间：
2014-04-10
影响因子：
2.9
通讯作者：
Mercer JG
中科院分区：
文献类型：
--
作者：
Bake T;Morgan DG;Mercer JG
每天给大鼠和小鼠提供短时间的可口的高脂肪饮食，会导致大量的暴饮暴食。对给予60%高脂饮食的SD-Dawley大鼠的暂时性食物摄取结构(使用TSE PhenoMaster/LabMaster系统进行评估)和代谢结果(口服葡萄糖耐量测试[OGTTS]，以及暗期葡萄糖和胰岛素谱)进行了研究：即刻进食(HF)，每天2小时-预定进入暗期(2小时-HF)，以及每天两次1小时-预定从1-2小时和10-11小时进入暗期(2小时×10-11小时-HF)。在预定的访问期间，对照饮食仍可用。HF大鼠的卡路里摄入量、体重增加、体脂质量和血浆胰岛素水平最高。两组动物的进食行为都迅速适应了进食行为，表现出大量进食/暴食行为，在2小时或2小时×1小时的进食过程中，分别有44%或53%的热量来自高脂饮食(S)。与HF组和对照组(CON)相比，两个计划喂养组的卡路里摄入量和体脂质量都处于中等水平。食物摄入量的时间分析表明，按计划喂养的大鼠摄入了大量暴饮型高脂肪食物，而没有习惯性地减少对照饮食的先前摄入量，这表明相对低热量状态不是导致暴饮暴食的原因，也不是驱动暴饮暴食的必要条件，并证实了先前的迹象，即暴饮暴食可能不是由下丘脑能量平衡神经肽驱动的。在OGTT中，两组按计划喂养的大鼠都有葡萄糖耐量受损，曲线下的葡萄糖和胰岛素面积较高，这与随意喂食HF的大鼠的反应相似，表明适宜的喂养计划代表着潜在的代谢威胁。计划喂食高脂饮食产生的代谢表型类似于强制(没有选择)的高脂肪喂养，这可能是饮食诱导肥胖的机制研究的一个更现实的平台。进食行为对预定可口饮食的快速适应在预定可口膳食之前没有证据表明进食减少(吞噬减少)按预定方案喂养的大鼠表现出不良的代谢症状。
Providing rats and mice with access to palatable high fat diets for a short period each day induces the consumption of substantial binge-like meals. Temporal food intake structure (assessed using the TSE PhenoMaster/LabMaster system) and metabolic outcomes (oral glucose tolerance tests [oGTTs], and dark phase glucose and insulin profiles) were examined in Sprague–Dawley rats given access to 60% high fat diet on one of 3 different feeding regimes: ad libitum access (HF), daily 2 h-scheduled access from 6 to 8 h into the dark phase (2 h-HF), and twice daily 1 h-scheduled access from both 1–2 h and 10–11 h into the dark phase (2 × 1 h-HF). Control diet remained available during the scheduled access period. HF rats had the highest caloric intake, body weight gain, body fat mass and plasma insulin. Both schedule-fed groups rapidly adapted their feeding behaviour to scheduled access, showing large meal/bingeing behaviour with 44% or 53% of daily calories consumed from high fat diet during the 2 h or 2 × 1 h scheduled feed(s), respectively. Both schedule-fed groups had an intermediate caloric intake and body fat mass compared to HF and control (CON) groups. Temporal analysis of food intake indicated that schedule-fed rats consumed large binge-type high fat meals without a habitual decrease in preceding intake on control diet, suggesting that a relative hypocaloric state was not responsible or required for driving the binge episode, and substantiating previous indications that binge eating may not be driven by hypothalamic energy balance neuropeptides. In an oGTT, both schedule-fed groups had impaired glucose tolerance with higher glucose and insulin area under the curve, similar to the response in ad libitum HF fed rats, suggesting that palatable feeding schedules represent a potential metabolic threat. Scheduled feeding on high fat diet produces similar metabolic phenotypes to mandatory (no choice) high fat feeding and may be a more realistic platform for mechanistic study of diet-induced obesity. Rapid adaptation of feeding behaviour to scheduled palatable diet access No evidence of reduced feeding (hypophagia) prior to scheduled palatable meals Schedule-fed rats exhibit adverse metabolic symptoms.
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影响因子：
2.9
作者：
Corwin, RL;Wojnicki, FHE;Young, MA
通讯作者：
Young, MA
影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
影响因子：
3.3
作者：
Mendoza, J;Angeles-Castellanos, M;Escobar, C
通讯作者：
Escobar, C
影响因子：
4.8
作者：
Vahl, Torsten P.;Drazen, Deborah L.;Woods, Stephen C.
通讯作者：
Woods, Stephen C.
影响因子：
3.3
作者：
Verwey, M.;Khoja, Z.;Amir, S.
通讯作者：
Amir, S.