Linking the Microbiota, Chronic Disease, and the Immune System.
Linking the Microbiota, Chronic Disease, and the Immune System.
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DOI：
10.1016/j.tem.2016.08.003
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发表时间：
2016-12
影响因子：
10.9
通讯作者：
Belkaid, Yasmine
中科院分区：
文献类型：
--
作者：
Hand, Timothy W.;Vujkovic-Cvijin, Ivan;Ridaura, Vanessa K.;Belkaid, Yasmine
慢性炎症性疾病是当今世界最重要的死亡原因，而且还在上升。我们现在知道，免疫驱动的炎症在这些疾病的病因学中是至关重要的，尽管导致它们发展的环境触发因素和细胞机制仍然是神秘的。许多慢性炎症性疾病与微生物区系向炎症构型的显著转变有关，这可以通过引起局部和全身炎症以及微生物区系衍生的代谢物的变化来影响宿主。这篇综述讨论了最近的发现，表明微生物区系的变化可能通过影响免疫系统而导致慢性疾病。
Chronic inflammatory diseases are the most important causes of mortality in the world today and are on the rise. We now know that immune-driven inflammation is critical in the etiology of these diseases, though the environmental triggers and cellular mechanisms that lead to their development are still mysterious. Many chronic inflammatory diseases are associated with significant shifts in the microbiota towards inflammatory configurations, which can affect the host both by inducing local and systemic inflammation and by alterations in microbiota-derived metabolites. This review discusses recent findings suggesting that shifts in the microbiota may contribute to chronic disease via effects on the immune system.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
2.9
作者：
Brenner DA;Paik YH;Schnabl B
通讯作者：
Schnabl B
影响因子：
11.1
作者：
Amar, Jacques;Chabo, Chantal;Waget, Aurelie;Klopp, Pascale;Vachoux, Christelle;Bermudez-Humaran, Luis G.;Smirnova, Natalia;Berge, Mathieu;Sulpice, Thierry;Lahtinen, Sampo;Ouwehand, Arthur;Langella, Philippe;Rautonen, Nina;Sansonetti, Philippe J.;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
17.1
作者：
Balmer, Maria L.;Slack, Emma;Macpherson, Andrew J.
通讯作者：
Macpherson, Andrew J.
特发性慢性腹泻的猕猴的治疗性蠕虫感染改变了结肠的炎症特征和粘膜微生物群。
影响因子：
6.7
作者：
Broadhurst MJ;Ardeshir A;Kanwar B;Mirpuri J;Gundra UM;Leung JM;Wiens KE;Vujkovic-Cvijin I;Kim CC;Yarovinsky F;Lerche NW;McCune JM;Loke P
通讯作者：
Loke P