The prognostic impact of RAS on overall survival following liver resection in early versus late-onset colorectal cancer patients.
The prognostic impact of RAS on overall survival following liver resection in early versus late-onset colorectal cancer patients.
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RAS对早发性和晚发性结直肠癌患者肝切除后总生存率的预后影响。
DOI：
10.1038/s41416-020-01169-w
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发表时间：
2021-03
影响因子：
8.8
通讯作者：
Eng C
中科院分区：
文献类型：
--
作者：
Jácome AA;Vreeland TJ;Johnson B;Kawaguchi Y;Wei SH;Nancy You Y;Vilar E;Vauthey JN;Eng C
分子畸变对早发性结直肠癌 (EOCRC) 与晚发性结直肠癌 (LOCRC) 患者结直肠肝转移 (CLM) 切除后生存的影响尚不清楚。对因 CLM 接受肝切除且 RAS、BRAF 和 MSI 状态已知的患者进行回顾性研究。以年龄作为分类变量和连续变量，分析了年龄对 RAS 突变的预后影响。该研究包括 573 名患者，其中 192 名患有 EOCRC，381 名患有 LOCRC。 CRC 发病年龄越小，LOCRC、EOCRC 和≤40 岁的 RAS 突变对总体生存的负面影响越大（风险比 (HR)，1.64（95% 置信区间 (CI)，1.23–2.20）、2.03（95% CI，1.30–3.17）和 2.97（95% CI， 1.44-6.14），分别。 年龄特异性死亡风险和线性回归分析还表明，RAS突变对EOCRC患者生存的影响比LOCRC患者更大（斜率：-4.07，95% CI -8.10至0.04，P = 0.047，R2 = 0.08）。在接受 CLM 切除的患者中，RAS 突变对 EOCRC 患者的生存有更大的负面影响，尤其是 ≤40 岁的患者比 EOCRC 患者的生存影响更大 患有 LOCRC，应被视为多学科治疗计划中的预后因素。
The impact of molecular aberrations on survival after resection of colorectal liver metastases (CLM) in patients with early-age-onset (EOCRC) versus late-age-onset colorectal cancer (LOCRC) is unknown. Patients who underwent liver resection for CLM with known RAS, BRAF and MSI status were retrospectively studied. The prognostic impact of RAS mutations by age was analysed with age as a categorical variable and a continuous variable. The study included 573 patients, 192 with EOCRC and 381 with LOCRC. The younger the age of onset of CRC, the greater the negative impact on overall survival of RAS mutations in the LOCRC, EOCRC, and ≤40 years (hazard ratio (HR), 1.64 (95% confidence interval (CI), 1.23–2.20), 2.03 (95% CI, 1.30–3.17), and 2.97 (95% CI, 1.44–6.14), respectively. Age-specific mortality risk and linear regression analysis also demonstrated that RAS mutations had a greater impact on survival in EOCRC than in LOCRC (slope: −4.07, 95% CI −8.10 to 0.04, P = 0.047, R2 = 0.08). Among patients undergoing CLM resection, RAS mutations have a greater negative influence on survival in patients with EOCRC, more so in patients ≤40 years, than in patients with LOCRC and should be considered as a prognostic factor in multidisciplinary treatment planning.
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影响因子：
120.7
作者：
Hedley, AA;Ogden, CL;Flegal, KM
通讯作者：
Flegal, KM
影响因子：
3.7
作者：
Narayan, Raja R.;Goldman, Debra A.;Kingham, T. Peter
通讯作者：
Kingham, T. Peter
影响因子：
16.9
作者：
Bailey CE;Hu CY;You YN;Bednarski BK;Rodriguez-Bigas MA;Skibber JM;Cantor SB;Chang GJ
通讯作者：
Chang GJ
影响因子：
28.2
作者：
Hong DS;Morris VK;El Osta B;Sorokin AV;Janku F;Fu S;Overman MJ;Piha-Paul S;Subbiah V;Kee B;Tsimberidou AM;Fogelman D;Bellido J;Shureiqi I;Huang H;Atkins J;Tarcic G;Sommer N;Lanman R;Meric-Bernstam F;Kopetz S
通讯作者：
Kopetz S
影响因子：
11.5
作者：
Lieu, Christopher H.;Golemis, Erica A.;Meyer, Joshua E.
通讯作者：
Meyer, Joshua E.