Cancer Chemotherapy in Early Life Significantly Alters the Maturation of Pain Processing.
Cancer Chemotherapy in Early Life Significantly Alters the Maturation of Pain Processing.
复制标题
DOI：
10.1016/j.neuroscience.2017.11.032
复制
发表时间：
2018-09-01
期刊：
影响因子：
3.3
通讯作者：
Hulse RP
中科院分区：
文献类型：
--
作者：
Hathway GJ;Murphy E;Lloyd J;Greenspon C;Hulse RP
顺铂暴露于生命早期会导致延迟但持久的机械和热超敏反应。生命早期的顺铂治疗不会导致DRG或脊髓中的感觉神经元损失。生命早期暴露于顺铂导致皮肤和脊髓中感觉神经纤维末端增加。儿科癌症治疗的进展已经导致十年生存率超过75%。铂类化疗（如顺铂）可诱导成人和儿童癌症患者的外周感觉神经病变。从出生到成年的时期代表了伤害感受系统的成熟期。在这里，我们研究了顺铂如何影响出生后的伤害感受系统的成熟。新生Wistar大鼠（出生后第7天（P））注射（i. p.）每天用媒介物（PBS）或顺铂（1 mg/kg）给药，连续5天。两组均未在治疗期间或治疗后立即出现机械或热超敏反应。在P22时，与溶剂组相比，顺铂组出现了机械（P < 0.05）和热（P < 0.0001）超敏反应。总DRG或背角神经元数量在P45时没有差异，但是在该年龄顺铂治疗的动物中表皮内神经纤维密度增加。在P45时，各组之间的IB 4 +ve、CGRP+ve和NF 200 +ve DRG神经元的百分比没有差异。与对照组相比，顺铂组在P45时TrkA+ve DRG神经元增加，此外腰椎背角中的TrkA、NF 200和vGLUT 2免疫反应性也增加。这些数据突出了儿科癌症化疗对疼痛通路成熟和晚年疼痛经历的影响。
Cisplatin exposure early in life causes delayed but long-lasting mechanical and heat hypersensitivity. Cisplatin treatment early in life does not lead to sensory neuron loss in DRG or spinal cord. Early-life exposure to cisplatin leads to increased sensory nerve fiber terminals in the skin and spinal cord. Advances in pediatric cancer treatment have led to a ten year survival rate greater than 75%. Platinum-based chemotherapies (e.g. cisplatin) induce peripheral sensory neuropathy in adult and pediatric cancer patients. The period from birth through to adulthood represents a period of maturation within nociceptive systems. Here we investigated how cisplatin impacts upon postnatal maturation of nociceptive systems. Neonatal Wistar rats (Postnatal day (P) 7) were injected (i.p.) daily with either vehicle (PBS) or cisplatin (1mg/kg) for five consecutive days. Neither group developed mechanical or thermal hypersensitivity immediately during or after treatment. At P22 the cisplatin group developed mechanical (P < 0.05) and thermal (P < 0.0001) hypersensitivity versus vehicle group. Total DRG or dorsal horn neuronal number did not differ at P45, however there was an increase in intraepidermal nerve fiber density in cisplatin-treated animals at this age. The percentage of IB4+ve, CGRP+ve and NF200+ve DRG neurons was not different between groups at P45. There was an increase in TrkA+ve DRG neurons in the cisplatin group at P45, in addition to increased TrkA, NF200 and vGLUT2 immunoreactivity in the lumbar dorsal horn versus controls. These data highlight the impact pediatric cancer chemotherapy has upon the maturation of pain pathways and later life pain experience.
登录
查看更多内容
影响因子：
2.5
作者：
Boada, M. Danilo;Houle, Timothy T.;Ririe, Douglas G.
通讯作者：
Ririe, Douglas G.
影响因子：
3.1
作者：
Gilchrist, L. S.;Marais, L.;Tanner, L.
通讯作者：
Tanner, L.
影响因子：
2.5
作者：
HIMES, BT;TESSLER, A
通讯作者：
TESSLER, A
DOI：
10.1016/0165-3806(94)90163-5
发表时间：
1994-10-14
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
COGGESHALL, RE;POWER, CM;FITZGERALD, M
通讯作者：
FITZGERALD, M
影响因子：
4.7
作者：
Giles, P. A.;Trezise, D. J.;King, A. E.
通讯作者：
King, A. E.