Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis.
Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis.
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循环抵抗素水平和结直肠癌风险：荟萃分析。
DOI：
10.1155/2016/7367485
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发表时间：
2016
影响因子：
--
通讯作者：
Yu M
中科院分区：
文献类型：
--
作者：
Yang G;Fan W;Luo B;Xu Z;Wang P;Tang S;Xu P;Yu M
目标。已发表的关于结直肠癌(CRC)患者抵抗素水平的数据相互矛盾且异质性。我们进行了一项观察性研究的荟萃分析，以检验循环抵抗素水平与结直肠癌发生的关系。方法：研究方法。通过MEDLINE、EMBASE、科学引文索引扩展数据库、CNKI和万方数据库检索截至2015年11月发表的可能符合条件的研究。用固定或随机效应模型计算的95%可信区间(CI)的合并加权平均差(WMD)估计效应。结果。我们的荟萃分析纳入了涉及965名患者的11项研究。合并效应显示，结直肠癌患者的抵抗素水平高于健康对照组(WMD值：1.4 7 ng/mL；95%可信区间：0.78~2.16)，且在所有研究中具有显著的异质性(I2=72%，p<；0.0001)。亚组分析和敏感性分析表明，研究质量、设计、样本类型和抵抗素测定可能解释了这种异质性。未观察到发表偏倚。结论。我们的荟萃分析表明，循环抵抗素水平升高与结直肠癌风险增加有关。考虑到可用研究的数量有限和显著的异质性，更大规模的精心设计的随机研究是有必要的。
Objectives. Published data on resistin levels in patients with colorectal cancer (CRC) were conflicting and heterogeneous. We conducted a meta-analysis of observational studies to examine the association of circulating resistin levels with carcinogenesis of the CRC. Methods. Potentially eligible studies published up to November 2015 were searched through MEDLINE, EMBASE, Science Citation Index Expanded database, CNKI, and WanFang database. The pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs) calculated by fixed- or random-effect model were used to estimate the effects. Results. A total of 11 studies involving 965 patients were admitted in our meta-analysis. The pooled effects indicated that resistin levels were higher in CRC patients compared to healthy controls (WMD: 1.47 ng/mL; 95% CI: 0.78 to 2.16), with significant heterogeneity across the studies (I 2 = 72%, p < 0.0001). Subgroup analyses and sensitivity analyses revealed that study quality, design, sample type, and resistin assays may account for this heterogeneity. No publication bias was observed. Conclusions. Our meta-analysis suggests that increased circulating resistin levels are associated with greater risk of colorectal cancer. Given the limited number of available studies and significant heterogeneity, larger well-designed randomized studies are warranted.
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影响因子：
11.2
作者：
Ho GY;Wang T;Gunter MJ;Strickler HD;Cushman M;Kaplan RC;Wassertheil-Smoller S;Xue X;Rajpathak SN;Chlebowski RT;Vitolins MZ;Scherer PE;Rohan TE
通讯作者：
Rohan TE
影响因子：
4
作者：
Hozo SP;Djulbegovic B;Hozo I
通讯作者：
Hozo I
影响因子：
3.3
作者：
De Pergola G;Silvestris F
通讯作者：
Silvestris F
影响因子：
11.4
作者：
Holcomb, IN;Kabakoff, RC;Hébert, CC
通讯作者：
Hébert, CC
影响因子：
5.4
作者：
Ikeda, Yoshito;Tsuchiya, Hiroyuki;Kogure, Kentaro
通讯作者：
Kogure, Kentaro