Oncotargets and Therapy Dovepress Meta-analysis of Associations of Interleukin-28b Polymorphisms Rs8099917 and Rs12979860 with Development of Hepatitis Virus-related Hepatocellular Carcinoma
Oncotargets and Therapy Dovepress Meta-analysis of Associations of Interleukin-28b Polymorphisms Rs8099917 and Rs12979860 with Development of Hepatitis Virus-related Hepatocellular Carcinoma
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肿瘤靶点和治疗 Dovepress 对白细胞介素 28b 多态性 Rs8099917 和 Rs12979860 与肝炎病毒相关肝细胞癌发生关联的荟萃分析
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影响因子：
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通讯作者：
Lequn Li
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作者：
Yu Zhang;Shao‐Liang Zhu;Jie Chen;Lequn Li
特此接受条款。未经Dove Medical Press Limited的进一步许可，允许将本作品用于非商业用途，前提是本作品具有适当的归属。关于这项工作的商业使用许可，请参见我们的术语背景的第4.2和5段：这项荟萃分析旨在评估白细胞介素-28 B多态性rs 8099917和rs 12979860与肝炎病毒相关肝细胞癌（HCC）发展可能相关性的现有证据。进行荟萃分析以检查白细胞介素-28 B rs 8099917 G/T和rs 12979860 T/C多态性与肝炎病毒相关HCC发生的相关性。计算比值比（OR）和95%置信区间（CI）。结果：共纳入10项研究，涉及2，529例病例和2，412例对照。rs 8099917的G等位基因和GT基因型与HBV相关性HCC的风险增加显著相关。相反，TT基因型与HBV相关性HCC的风险降低显著相关（显性模型，OR 0.68，95%CI 0.51-0.91，P=0.01）。在中国患者亚组和对照组中观察到相似的结果。在汇总数据集中，rs 12979860的T等位基因和TT基因型显示与HCC风险增加显著相关。根据所有五种遗传模型，基于种族和病因的亚组分析显示，rs 12979860多态性与高加索人的HCC风险显著相关，尤其是丙型肝炎病毒相关的HCC。相比之下，只有rs 12979860的TT基因型与HBV相关HCC的风险增加显著相关，特别是在亚洲人中。结论：rs 8099917的G等位基因可能增加HBV相关性HCC的风险，而野生型TT基因型可能对HBV相关性HCC具有保护作用。rs 12979860的T等位基因可能增加高加索人患HCC的风险，尤其是丙型肝炎病毒相关的HCC。rs 12979860的TT基因型可能增加HBV相关HCC的风险，尤其是在亚洲人中。这些结论应该在大型、精心设计的研究中得到验证。
hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms Background: This meta-analysis aimed to assess available evidence on possible associations of interleukin-28B polymorphisms rs8099917 and rs12979860 with development of hepatitis virus-related hepatocellular carcinoma (HCC).structure databases were systematically searched to identify relevant studies. Meta-analyses were performed to examine the association of interleukin-28B rs8099917 G/T and rs12979860 T/C polymorphisms with development of hepatitis virus-related HCC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: A total of ten studies involving 2,529 cases and 2,412 controls were included. The G-allele and GT genotype of rs8099917 were significantly associated with increased risk of hepatitis B virus (HBV)-related HCC Conversely, the TT genotype was found to be significantly associated with lower risk of HBV-related HCC (dominant model, OR 0.68, 95% CI 0.51–0.91, P=0.01). Similar results were observed in the subgroup of Chinese patients and controls. In the pooled data set, the T-allele and TT genotype of rs12979860 showed a significant association with increased HCC risk Subgroup analysis based on ethnicity and etiology showed rs12979860 polymorphism to be significantly associated with HCC risk in Caucasians, especially hepatitis C virus-related HCC, according to all five genetic models. In contrast, only the TT genotype of rs12979860 was found to be significantly associated with increased risk of HBV-related HCC, especially in Asians. Conclusion: The G-allele of rs8099917 may confer elevated risk of HBV-related HCC, while the wild-type TT genotype may protect against the disease. The T-allele of rs12979860 may increase the risk of HCC, in Caucasians, especially hepatitis C virus-related HCC. The TT genotype of rs12979860 may confer increased risk of HBV-related HCC, especially in Asians. These conclusions should be verified in large, well-designed studies.
影响因子：
9.7
作者：
Bouchard, Michael J.;Navas-Martin, Sonia
通讯作者：
Navas-Martin, Sonia
影响因子：
25.7
作者：
Zhang, Leiliang;Jilg, Nikolaus;Shao, Run-Xuan;Lin, Wenyu;Fusco, Dahlene N.;Zhao, Hong;Goto, Kaku;Peng, Lee F.;Chen, Wen-Chi;Chung, Raymond T.
通讯作者：
Chung, Raymond T.