Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges.
Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges.
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DOI：
10.1016/j.canlet.2010.11.014
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发表时间：
2011-06-28
期刊：
影响因子：
9.7
通讯作者：
Navas-Martin, Sonia
中科院分区：
文献类型：
--
作者：
Bouchard, Michael J.;Navas-Martin, Sonia
在世界范围内，肝细胞癌（HCC）是最常见的癌症之一。据认为，80%的肝细胞癌与B型肝炎（HBV）或丙型肝炎（HCV）病毒的慢性感染有关。慢性HBV和HCV感染可以以类似的方式改变肝细胞生理学，并可能利用类似的机制影响HCC的发展。在理解HBV和HCV的分子生物学和识别HBV和HCV感染改变的细胞信号转导途径方面取得了重大进展。虽然HBV和HCV感染与HCC发展之间的确切分子机制尚未完全了解，但有相当多的证据表明，对这些病毒感染的炎症反应，肝细胞的相关破坏和再生，以及HBV或HCV编码蛋白的活性，都有助于肝细胞转化。在这篇综述中，我们总结了在定义可能将HBV和HCV感染与HCC发展联系起来的机制方面的进展，讨论了直接定义HBV和HCV相关HCC的过程的挑战，并描述了仍有待探索的领域。
Worldwide, hepatocellular carcinoma (HCC) is one of the most common cancers. It is thought that 80% of hepatocellular carcinomas are linked to chronic infections with the hepatitis B (HBV) or hepatitis C (HCV) viruses. Chronic HBV and HCV infections can alter hepatocyte physiology in similar ways and may utilize similar mechanisms to influence the development of HCC. There has been significant progress towards understanding the molecular biology of HBV and HCV and identifying the cellular signal transduction pathways that are altered by HBV and HCV infections. Although the precise molecular mechanisms that link HBV and HCV infections to the development of HCC are not entirely understood, there is considerable evidence that both inflammatory responses to infections with these viruses, and associated destruction and regeneration of hepatocytes, as well as activities of HBV- or HCV-encoded proteins, contribute to hepatocyte transformation. In this review, we summarize progress in defining mechanisms that may link HBV and HCV infections to the development of HCC, discuss the challenges of directly defining the processes that underlie HBV- and HCV-associated HCC, and describe areas that remain to be explored.
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影响因子：
5.4
作者：
Beran, Rudolf K. F.;Lindenbach, Brett D.;Pyle, Anna Marie
通讯作者：
Pyle, Anna Marie
影响因子：
4.8
作者：
Bureau, C;Bernad, J;Pipy, B
通讯作者：
Pipy, B
影响因子：
5.4
作者：
Becker, SA;Lee, TH;Slagle, BL
通讯作者：
Slagle, BL
影响因子：
5.4
作者：
Bouchard, M;Giannakopoulos, S;Schneider, RJ
通讯作者：
Schneider, RJ
DOI：
10.3390/v1020104
发表时间：
2009-09
期刊：
Viruses
影响因子：
--
作者：
Bengsch B;Thimme R;Blum HE
通讯作者：
Blum HE