Mechanisms and insights into drug resistance in cancer.
Mechanisms and insights into drug resistance in cancer.
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DOI：
10.3389/fphar.2013.00028
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发表时间：
2013
影响因子：
5.6
通讯作者：
Borden KL
中科院分区：
文献类型：
--
作者：
Zahreddine H;Borden KL
癌症耐药性仍然是医学肿瘤学的主要障碍。在临床上，耐药性可以在癌症治疗之前或作为癌症治疗的结果出现。在这篇综述中，我们讨论了癌细胞抵抗治疗的不同机制，包括药物转运和代谢的改变，药物靶点的突变和扩增，以及可能导致细胞凋亡受损的基因重组。肿瘤异质性也可能导致耐药性，其中小的细胞亚群可能获得或随机地已经具有使它们能够在选择性药物压力下出现的一些特征。使问题更具挑战性，其中一些耐药途径导致多药耐药性，产生更难克服的临床问题。我们提供了这些机制的例子，以及对这些过程的理解如何影响下一代癌症疗法的一些见解。
Cancer drug resistance continues to be a major impediment in medical oncology. Clinically, resistance can arise prior to or as a result of cancer therapy. In this review, we discuss different mechanisms adapted by cancerous cells to resist treatment, including alteration in drug transport and metabolism, mutation and amplification of drug targets, as well as genetic rewiring which can lead to impaired apoptosis. Tumor heterogeneity may also contribute to resistance, where small subpopulations of cells may acquire or stochastically already possess some of the features enabling them to emerge under selective drug pressure. Making the problem even more challenging, some of these resistance pathways lead to multidrug resistance, generating an even more difficult clinical problem to overcome. We provide examples of these mechanisms and some insights into how understanding these processes can influence the next generation of cancer therapies.
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影响因子：
30.8
作者：
Campbell, Peter J.;Stephens, Philip J.;Pleasance, Erin D.;O'Meara, Sarah;Li, Heng;Santarius, Thomas;Stebbings, Lucy A.;Leroy, Catherine;Edkins, Sarah;Hardy, Claire;Teague, Jon W.;Menzies, Andrew;Goodhead, Ian;Turner, Daniel J.;Clee, Christopher M.;Quail, Michael A.;Cox, Antony;Brown, Clive;Durbin, Richard;Hurles, Matthew E.;Edwards, Paul A. W.;Bignell, Graham R.;Stratton, Michael R.;Futreal, P. Andrew
通讯作者：
Futreal, P. Andrew
影响因子：
20.3
作者：
Frassanito, MA;Cusmai, A;Dammacco, F
通讯作者：
Dammacco, F
影响因子：
16.8
作者：
Caulin AF;Maley CC
通讯作者：
Maley CC
影响因子：
56.9
作者：
Engelman, Jeffrey A.;Zejnullahu, Kreshnik;Janne, Pasi A.
通讯作者：
Janne, Pasi A.
影响因子：
11.5
作者：
Bidard, Francois-Clement;Vincent-Salomon, Anne;Pierga, Jean-Yves
通讯作者：
Pierga, Jean-Yves