Peto's Paradox: evolution's prescription for cancer prevention.
Peto's Paradox: evolution's prescription for cancer prevention.
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DOI：
10.1016/j.tree.2011.01.002
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发表时间：
2011-04
影响因子：
16.8
通讯作者：
Maley CC
中科院分区：
文献类型：
--
作者：
Caulin AF;Maley CC
多细胞生物的进化需要抑制癌症。如果每个细胞都有癌变的可能性，那么与小的、寿命短的生物体相比，大的、寿命长的生物体患癌症的风险应该更高。身体大小和癌症风险之间缺乏相关性被称为Peto的Parkway。拥有比人类多1,000倍细胞的动物并没有表现出增加的癌症风险，这表明自然机制可以比人类细胞更有效地抑制癌症1,000倍。由于癌症已被证明难以治愈，人们的注意力已转向癌症预防。在这篇综述中，就像制药公司开采天然产品一样，我们试图了解进化是如何抑制癌症的，以最终改善人类的癌症预防。
The evolution of multicellularity required the suppression of cancer. If every cell has some chance of becoming cancerous, large, long-lived organisms should have an increased risk of developing cancer compared to small, short-lived organisms. The lack of correlation between body size and cancer risk is known as Peto’s Paradox. Animals with 1,000 times more cells than humans do not exhibit an increased cancer risk, suggesting that natural mechanisms can suppress cancer 1,000 times more effectively than is done in human cells. Because cancer has proven difficult to cure, attention has turned to cancer prevention. In this review, like pharmaceutical companies mining natural products, we seek to understand how evolution has suppressed cancer to ultimately develop improved cancer prevention in humans.
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影响因子：
8
作者：
Ise, K;Nakamura, K;Katsuki, M
通讯作者：
Katsuki, M
DOI：
10.1073/pnas.0607057103
发表时间：
2006-11-28
影响因子：
11.1
作者：
Bielas, Jason H.;Loeb, Keith R.;Loeb, Lawrence A.
通讯作者：
Loeb, Lawrence A.
DOI：
10.1038/nrc2892
发表时间：
2010-08
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
人类癌基因组中体细胞突变的模式。
影响因子：
64.8
作者：
Greenman, Christopher;Stephens, Philip;Smith, Raffaella;Dalgliesh, Gillian L.;Hunter, Christopher;Bignell, Graham;Davies, Helen;Teague, Jon;Butler, Adam;Edkins, Sarah;O'Meara, Sarah;Vastrik, Imre;Schmidt, Esther E.;Avis, Tim;Barthorpe, Syd;Bhamra, Gurpreet;Buck, Gemma;Choudhury, Bhudipa;Clements, Jody;Cole, Jennifer;Dicks, Ed;Forbes, Simon;Gray, Kris;Halliday, Kelly;Harrison, Rachel;Hills, Katy;Hinton, Jon;Jenkinson, Andy;Jones, David;Menzies, Andy;Mironenko, Tatiana;Perry, Janet;Raine, Keiran;Richardson, Dave;Shepherd, Rebecca;Small, Alexandra;Tofts, Calli;Varian, Jennifer;Webb, Tony;West, Sofie;Widaa, Sara;Yates, Andy;Cahill, Daniel P.;Louis, David N.;Goldstraw, Peter;Nicholson, Andrew G.;Brasseur, Francis;Looijenga, Leendert;Weber, Barbara L.;Chiew, Yoke-Eng;deFazio, Anna;Greaves, Mel F.;Green, Anthony R.;Campbell, Peter;Birney, Ewan;Easton, Douglas F.;Chenevix-Trench, Georgia;Tan, Min-Han;Khoo, Sok Kean;Teh, Bin Tean;Yuen, Siu Tsan;Leung, Suet Yi;Wooster, Richard;Futreal, P. Andrew;Stratton, Michael R.
通讯作者：
Stratton, Michael R.
影响因子：
64.8
作者：
Koebel, Catherine M.;Vermi, William;Schreiber, Robert D.
通讯作者：
Schreiber, Robert D.