Psychological therapies in patients with irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials.
Psychological therapies in patients with irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials.
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DOI：
10.1155/2015/549308
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发表时间：
2015
影响因子：
2
通讯作者：
Murad MH
中科院分区：
文献类型：
--
作者：
Altayar O;Sharma V;Prokop LJ;Sood A;Murad MH
背景资料。肠易激综合征(IBS)是一种知之甚少的疾病，几乎没有有效的治疗方法。心理社会因素被认为是IBS的发病机制之一。目标。评价心理疗法在IBS治疗中的证据。方法：研究方法。我们搜索了截至2014年2月6日的6个医学数据库，以寻找治疗IBS的心理疗法的随机对照试验(RCT)。两名独立的评价者确定了随机对照试验，提取了数据，并评估了试验质量。我们使用随机效应模型来汇集所有试验的标准化平均差(SMD)和95%可信区间(CI)。结果。纳入15篇主要评价认知行为疗法的随机对照试验。心理治疗与改善肠易激综合征症状严重程度(SMD−0.618；95%CI：−0.853至−0.383)、IBS生活质量(SMD 0.604；95%CI：0.440至0.768)以及腹痛(SMD−0.282；95%CI：−0.562至−0.001)有关。在腹泻或便秘方面没有观察到有统计学意义的效果。限制。这些试验存在更大的偏倚风险，而且总体样本量小，导致不准确。结论。心理治疗可改善IBS患者的生活质量和症状严重程度。所记录的效应大小为中到大，具有临床意义。
Background. Irritable bowel syndrome (IBS) is a poorly understood disease with few effective treatments. Psychosocial factors are believed to contribute to the pathogenesis of IBS. Objective. To evaluate the evidence for psychological therapies in IBS treatment. Methods. We searched six medical databases through February 6, 2014, for randomized controlled trials (RCTs) of psychological therapies for the treatment of IBS. Two independent reviewers identified the RCTs, extracted the data, and assessed trial quality. We used the random-effect model to pool standardized mean difference (SMD) and 95% confidence interval (CI) across trials. Results. 15 RCTs that mostly evaluated cognitive behavioral therapy were included. Psychological therapies were associated with improvement in IBS symptoms severity scales (SMD −0.618; 95% CI: −0.853 to −0.383), IBS-Quality of Life (SMD 0.604; 95% CI: 0.440 to 0.768), and abdominal pain (SMD −0.282; 95% CI: −0.562 to −0.001). No statistically significant effect was observed on diarrhea or constipation. Limitations. The trials were at increased risk of bias and the overall sample size was small leading to imprecision. Conclusion. Psychological therapies may improve the quality of life and symptom severity in IBS. The effect size noted is moderate to large and is clinically meaningful.
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影响因子：
29.4
作者：
Drossman, DA;Toner, BB;Bangdiwala, SI
通讯作者：
Bangdiwala, SI
影响因子：
3.1
作者：
Heitkemper, M;Burr, RL;Bond, EF
通讯作者：
Bond, EF
影响因子：
9.8
作者：
Drossman, Douglas;Morris, Carolyn B.;Bangdiwala, Shrikant I.
通讯作者：
Bangdiwala, Shrikant I.
影响因子：
1.8
作者：
FitzGerald, Leah Z.;Kehoe, Priscilla;Sinha, Karabi
通讯作者：
Sinha, Karabi
正念训练减少了女性肠易激综合症的严重程度：一项随机对照试验的结果。
DOI：
10.1038/ajg.2011.184
发表时间：
2011-09
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Gaylord SA;Palsson OS;Garland EL;Faurot KR;Coble RS;Mann JD;Frey W;Leniek K;Whitehead WE
通讯作者：
Whitehead WE