Arousal from sleep shortens sympathetic burst latency in humans
Arousal from sleep shortens sympathetic burst latency in humans
复制标题
睡眠唤醒可缩短人类交感神经爆发潜伏期
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
B. Morgan
中科院分区：
文献类型：
--
作者：
A. Xie;J. Skatrud;D. Puleo;B. Morgan
1 肌肉神经中交感神经活动的爆发通过窦主动脉压力反射与心动周期锁相。非快速眼动 (NREM) 睡眠中的声学唤醒会缩短心电图 (ECG) R 波与相应交感神经爆发峰值之间通常不变的间隔；然而，其他形式的睡眠中断（即自发性觉醒和呼吸暂停引起的觉醒）对这种时间关系的影响尚不清楚。 2 我们同时记录了 7 名健康人和 3 名睡眠呼吸暂停综合征患者在 NREM 睡眠期间腓神经（神经内电极）和心电图（表面电极）的肌肉交感神经活动。 3 在 7 名受试者中，与稳定 NREM 睡眠期间的潜伏期 (1.369 ± 0.023 s) 相比，自发 K 复合波 (1.297 ± 0.024 s，平均值 ± s.e.m.) 和自发性唤醒 (1.268 ± 0.044 s) 后的突发潜伏期缩短。在六名在睡眠期间表现出自发性呼吸暂停的受试者中，相对于脑电图 (EEG) 和呼吸稳定的睡眠而言，呼吸暂停本身并没有改变突发潜伏期（1.313 ± 0.038 与 1.342 ± 0.026 秒）；然而，在呼吸暂停引起的脑电图扰动后，突发潜伏期减少（1.214 ± 0.034 s）。 4 唤醒引起的交感神经爆发潜伏期的减少可能反映了交感神经流出的压力感受反射缓冲的暂时减少。如果是这样，睡眠期间动脉压扰动的幅度（例如由睡眠呼吸障碍和周期性腿部运动引起的动脉压扰动）可能会因觉醒而加剧。
1 Bursts of sympathetic activity in muscle nerves are phase‐locked to the cardiac cycle by the sinoaortic baroreflexes. Acoustic arousal from non‐rapid eye movement (NREM) sleep reduces the normally invariant interval between the R‐wave of the electrocardiogram (ECG) and the peak of the corresponding sympathetic burst; however, the effects of other forms of sleep disruption (i.e. spontaneous arousals and apnoea‐induced arousals) on this temporal relationship are unknown. 2 We simultaneously recorded muscle sympathetic nerve activity in the peroneal nerve (intraneural electrodes) and the ECG (surface electrodes) in seven healthy humans and three patients with sleep apnoea syndrome during NREM sleep. 3 In seven subjects, burst latencies were shortened subsequent to spontaneous K complexes (1.297 ± 0.024 s, mean ± s.e.m.) and spontaneous arousals (1.268 ± 0.044 s) compared with latencies during periods of stable NREM sleep (1.369 ± 0.023 s). In six subjects who demonstrated spontaneous apnoeas during sleep, apnoea per se did not alter burst latency relative to sleep with stable electroencephalogram (EEG) and breathing (1.313 ± 0.038 vs. 1.342 ± 0.026 s); however, following apnoea‐induced EEG perturbations, burst latencies were reduced (1.214 ± 0.034 s). 4 Arousal‐induced reduction in sympathetic burst latency may reflect a temporary diminution of baroreflex buffering of sympathetic outflow. If so, the magnitude of arterial pressure perturbations during sleep (e.g. those caused by sleep disordered breathing and periodic leg movements) may be augmented by arousal.
影响因子：
3.3
作者：
R. Rea;B. Wallin
通讯作者：
R. Rea;B. Wallin
用于分析人体肌肉交感神经活动的信号平均技术。
DOI：
10.1152/jappl.1992.73.1.376
发表时间：
1992
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Birkett,CL;Ray,CA;Anderson,EA;Rea,RF
通讯作者：
Rea,RF
腹外侧和背侧髓质交感神经元的激活顺序。
DOI：
10.1152/ajpregu.1983.245.3.r438
发表时间：
1983
期刊：
The American journal of physiology
影响因子：
--
作者：
Barman,SM;Gebber,GL
通讯作者：
Gebber,GL