Sleep loss and the inflammatory response in mice under chronic environmental circadian disruption.
Sleep loss and the inflammatory response in mice under chronic environmental circadian disruption.
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DOI：
10.1371/journal.pone.0063752
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Paul KN
中科院分区：
文献类型：
--
作者：
Brager AJ;Ehlen JC;Castanon-Cervantes O;Natarajan D;Delisser P;Davidson AJ;Paul KN
轮班工作和跨时区旅行会导致睡眠不足和多种疾病。在这里，我们检查了长期暴露于环境昼夜节律紊乱 (ECD) 期间的睡眠/觉醒动态，以及与 ECD 相关的慢性部分睡眠缺失是否会影响轮班相关炎症性疾病的诱发。在三个月的 ECD 中遥测记录睡眠和清醒状态，其中明暗周期的黑暗阶段每周提前 6 小时。三个月的 ECD 方案会导致每周的睡眠（NREM 和 REM）和觉醒过程暂时重组，导致每周相对于基线水平约减少 10% 的净睡眠损失。另一组小鼠接受了 ECD 或强制觉醒 (IW) 方案，旨在模拟 ECD 下的睡眠量，持续一个月。 Fos 免疫反应性 (IR) 在睡眠-觉醒调节区域进行量化：伏隔核 (NAc)、基底前脑 (BF) 和内侧视前区 (MnPO)。为了评估炎症反应，用脂多糖 (LPS) 处理躯干血液，然后测量 IL-6 的释放。 Fos-IR 在 IW 小鼠的 NAc、BF 和 MnPO 中最强。接受 ECD 的小鼠对 LPS 的炎症反应升高，但接受 IW 的小鼠则没有升高。因此，ECD 下发生的净睡眠损失与病理性免疫反应无关。
Shift work and trans-time zone travel lead to insufficient sleep and numerous pathologies. Here, we examined sleep/wake dynamics during chronic exposure to environmental circadian disruption (ECD), and if chronic partial sleep loss associated with ECD influences the induction of shift-related inflammatory disorder. Sleep and wakefulness were telemetrically recorded across three months of ECD, in which the dark-phase of a light-dark cycle was advanced weekly by 6 h. A three month regimen of ECD caused a temporary reorganization of sleep (NREM and REM) and wake processes across each week, resulting in an approximately 10% net loss of sleep each week relative to baseline levels. A separate group of mice were subjected to ECD or a regimen of imposed wakefulness (IW) aimed to mimic sleep amounts under ECD for one month. Fos-immunoreactivity (IR) was quantified in sleep-wake regulatory areas: the nucleus accumbens (NAc), basal forebrain (BF), and medial preoptic area (MnPO). To assess the inflammatory response, trunk blood was treated with lipopolysaccharide (LPS) and subsequent release of IL-6 was measured. Fos-IR was greatest in the NAc, BF, and MnPO of mice subjected to IW. The inflammatory response to LPS was elevated in mice subjected to ECD, but not mice subjected to IW. Thus, the net sleep loss that occurs under ECD is not associated with a pathological immune response.
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影响因子：
4.4
作者：
Chapdelaine, Simon;Paquet, Jean;Dumont, Marie
通讯作者：
Dumont, Marie
影响因子：
3.4
作者：
Deboer, Tom;Ruijgrok, Guido;Meijer, Johanna H.
通讯作者：
Meijer, Johanna H.
DOI：
10.4049/jimmunol.1102715
发表时间：
2012-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Logan RW;Zhang C;Murugan S;O'Connell S;Levitt D;Rosenwasser AM;Sarkar DK
通讯作者：
Sarkar DK
DOI：
10.4049/jimmunol.1001026
发表时间：
2010-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castanon-Cervantes O;Wu M;Ehlen JC;Paul K;Gamble KL;Johnson RL;Besing RC;Menaker M;Gewirtz AT;Davidson AJ
通讯作者：
Davidson AJ
DOI：
10.1523/jneurosci.3559-12.2012
发表时间：
2012-11-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Sellix MT;Evans JA;Leise TL;Castanon-Cervantes O;Hill DD;DeLisser P;Block GD;Menaker M;Davidson AJ
通讯作者：
Davidson AJ