Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity.
Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity.
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DOI：
10.1016/j.neuroimage.2018.09.035
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发表时间：
2019-01-01
期刊：
影响因子：
5.7
通讯作者：
Wise RG
中科院分区：
文献类型：
--
作者：
Germuska M;Chandler HL;Stickland RC;Foster C;Fasano F;Okell TW;Steventon J;Tomassini V;Murphy K;Wise RG
双校准fMRI是一种多参数技术，可用于定量静息氧提取分数（OEF）、脑代谢耗氧绝对速率（CMRO 2）、脑血管反应性（CVR）和基线灌注（CBF）。它结合了高碳酸和高氧气体挑战期间动脉自旋标记（ASL）和血氧水平依赖性（BOLD）信号变化的测量。在这里，我们提出了一个扩展这种方法，允许同时量化的有效氧扩散率的毛细管网络（DC）。有效氧扩散率的范围是一个信息的生物标志物和有用的辅助CMRO 2，可能提供微血管健康的非侵入性度量，这是已知的一系列神经系统疾病的干扰。我们在一组健康志愿者（n = 19）中展示了这种新方法，无论是在休息时还是在视觉刺激时。发现有效氧扩散率在休息和激活期间与CMRO 2高度相关，这与之前的PET观察结果一致，即代谢需氧量与有效扩散率之间存在强相关性。发现功能激活期间有效扩散率的增加与先前报道的毛细血管血容量增加一致，支持测得的氧扩散率对微血管生理学敏感的观点。我们提出了一个新的框架，用于分析校准的功能磁共振成像映射CMRO 2和氧扩散率在大脑中。该框架与建模研究和在体内休息和视觉刺激期间检查。氧扩散率被认为是高度相关的CMRO 2，一个紧密的结构-功能关系的证据。
Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the resting oxygen extraction fraction (OEF), the absolute rate of cerebral metabolic oxygen consumption (CMRO2), cerebral vascular reactivity (CVR) and baseline perfusion (CBF). It combines measurements of arterial spin labelling (ASL) and blood oxygenation level dependent (BOLD) signal changes during hypercapnic and hyperoxic gas challenges. Here we propose an extension to this methodology that permits the simultaneous quantification of the effective oxygen diffusivity of the capillary network (DC). The effective oxygen diffusivity has the scope to be an informative biomarker and useful adjunct to CMRO2, potentially providing a non-invasive metric of microvascular health, which is known to be disturbed in a range of neurological diseases. We demonstrate the new method in a cohort of healthy volunteers (n = 19) both at rest and during visual stimulation. The effective oxygen diffusivity was found to be highly correlated with CMRO2 during rest and activation, consistent with previous PET observations of a strong correlation between metabolic oxygen demand and effective diffusivity. The increase in effective diffusivity during functional activation was found to be consistent with previously reported increases in capillary blood volume, supporting the notion that measured oxygen diffusivity is sensitive to microvascular physiology. We propose a new framework for the analysis of calibrated fMRI to map CMRO2 and oxygen diffusivity in the brain. The framework is examined with modelling studies and in-vivo at rest and during visual stimulation. Oxygen diffusivity is found to be highly correlated with CMRO2, evidence of a tight structural-functional relationship.
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DOI：
10.3389/fnene.2010.00008
发表时间：
2010
期刊：
Frontiers in neuroenergetics
影响因子：
--
作者：
Buxton RB
通讯作者：
Buxton RB
影响因子：
10.2
作者：
HANSEN, PC
通讯作者：
HANSEN, PC
影响因子：
6.3
作者：
Gjedde, A;Johannsen, P;Ostergaard, L
通讯作者：
Ostergaard, L
DOI：
10.1097/00004647-200003000-00007
发表时间：
2000-03-01
影响因子：
6.3
作者：
Hyder, F;Kennan, RP;Rothman, D
通讯作者：
Rothman, D
DOI：
10.1097/00004647-199701000-00009
发表时间：
1997-01-01
影响因子：
6.3
作者：
Buxton, RB;Frank, LR
通讯作者：
Frank, LR