Evaluating Plasma Skimming with Whole Blood in Small Gap Region Imitating Clearance of Blood Pumps
Evaluating Plasma Skimming with Whole Blood in Small Gap Region Imitating Clearance of Blood Pumps
复制标题
模拟血泵的间隙，在小间隙区域评估全血的血浆撇取
DOI：
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
W. Hijikata
中科院分区：
文献类型：
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作者：
M. Jiang;Tomotaka Murashige;D. Sakota;W. Hijikata
血浆撇除是排出血细胞比容低于进料血细胞比容的现象，该现象在具有泊氏流动的微容器中自然发生。它在Poietille流中得到了广泛的研究。此外，血浆撇除也已在血泵中被观察和研究，因为其通过将血细胞撇出小间隙来防止溶血的潜力。然而，在使用全血的血泵中是否发生血浆撇除尚未得到验证。此外，旋转速度和间隙尺寸的独立影响尚未得到澄清。因此，为了将血浆撇除技术应用于血泵的研制奠定基础，并分别研究转速和间隙大小对血浆撇除的影响，我们设计了一种简化的几何装置，该装置不仅模拟了血泵间隙内的流动，而且提供了不同的转速和间隙大小条件。我们首先使用初始红细胞压积为44%的全血进行血浆撇除的验证试验，差距大小在10 μm至240 μm之间变化，间隔为10 μm。当差距小于70 μm，转速为800 rpm时，验证发生血浆撇除。由于确认了血浆撇除，我们采用了30%红细胞比容的血液，并进行了以下试验，以分别评价600 rpm、700 rpm和800 rpm转速的影响。结果，随着转速从600 rpm增加到800 rpm，采样血液的血细胞比容下降。当差距调整为50 μm时，在800 rpm下，红细胞压积最低，为16%。该研究进一步促进了将血浆撇除应用于具有更高血容量的血泵的可能性。
Plasma skimming is the phenomenon whereby the discharge hematocrit is lower than feed hematocrit naturally occurring in the microvessels with Poiseuille flow. It has been studied in Poiseuille flow extensively. Besides, plasma skimming has also been observed and investigated in blood pumps due to its potential to prevent hemolysis by skimming blood cells out of the small gap. However, whether plasma skimming occurs in blood pumps with whole blood has not been verified. Additionally, the independent influence of rotational speed and gap size has not been clarified. Therefore, in order to lay the foundation of applying plasma skimming to the development of blood pumps and also investigate the influence of rotational speed and gap size on plasma skimming respectively, we designed a simplified geometric device which not only imitates the flow inside clearances of blood pumps, but also provides different rotational speed and gap size conditions. We first conducted the verification tests of plasma skimming using whole blood with an initial hematocrit of 44% and the gap size was varied from 10 μm to 240 μm with 10 μm interval. The plasma skimming was verified occurring when the gap was less than 70 μm at a rotational speed of 800 rpm. Since plasma skimming was confirmed, we employed 30% hematocrit blood and performed the following tests to evaluate the influence of rotational speed of 600 rpm, 700 rpm, and 800 rpm respectively. As a result, the hematocrit of sampled blood declined as the rotational speed increased from 600 rpm to 800 rpm. And there was the lowest hematocrit of 16% when the gap was adjusted to 50 μm gap size at 800 rpm. This study further promotes the possibility of applying plasma skimming to the blood pumps with higher hemocapability.
DOI：
10.1115/1.2895708
发表时间：
1994-02-01
影响因子：
1.7
作者：
ENDEN, G;POPEL, AS
通讯作者：
POPEL, AS