Plasma Vanin-1 as a Novel Biomarker of Sepsis for Trauma Patients: A Prospective Multicenter Cohort Study.
Plasma Vanin-1 as a Novel Biomarker of Sepsis for Trauma Patients: A Prospective Multicenter Cohort Study.
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血浆 Vanin-1 作为创伤患者败血症的新型生物标志物：一项前瞻性多中心队列研究。
DOI：
10.1007/s40121-021-00414-w
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发表时间：
2021-06
影响因子：
5.4
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Lu H;Zhang A;Wen D;Du J;Sun J;Qiao L;Du D;Gu W;Jiang J
Vanin-1在氧化应激和炎症反应中起关键作用。然而，其与创伤性败血症的关系尚不清楚。我们研究的目的是评估血浆vanin-1是否可以用于创伤性败血症的早期预测。在这项三阶段前瞻性队列研究中，纳入了2015年1月至2018年10月在两家医院住院的严重创伤患者。采用酶联免疫吸附试验（ELISA）检测血浆vanin-1水平。采用logistic回归模型确定各变量与创伤性脓毒症的相关性，并分析受试者工作特征（ROC）曲线以评价诊断效率。共招募了426名创伤患者（发现组22名，内部测试组283名，外部验证组121名）和16名健康志愿者。创伤患者血浆vanin-1明显高于健康志愿者（P < 0.05）。发现创伤组脓毒症患者血浆vanin-1高于非脓毒症患者（P < 0.05）。在内试验队列中，创伤后第1天血浆vanin-1与脓毒症的发生率显著相关（OR = 3.92, 95% CI 2.68-5.72, P = 1.62 × 10−12）。作为预测性生物标志物，vanin-1的曲线下面积（AUC） （0.82, 95% CI 0.77-0.87）优于c反应蛋白（CRP） （0.62, 95% CI 0.56-0.68, P < 0.0001）、降钙素原（PCT） （0.66, 95% CI 0.60-0.71, P < 0.0001）和急性生理和慢性健康评估II (APACHE II) （0.71, 95% CI 0.65-0.76, P = 6.70 × 10−3）。在外部验证队列中进一步验证了相关性（OR = 4.26, 95% CI 2.22-8.17, P = 1.28 × 10−5），AUC为0.83 （95% CI 0.75-0.89）。Vanin-1也能提高APACHEⅱ的诊断效率（AUC = 0.85）。我们的研究表明，创伤患者血浆vanin-1升高，并且与败血症的风险独立相关。Vanin-1可能是早期预测创伤性败血症的潜在生物标志物。Clinicaltrials.gov识别码，NCT01713205。在线版本包含补充材料，可在10.1007/s40121-021-00414-w获得。
Vanin-1 plays a pivotal role in oxidative stress and the inflammatory response. However, its relationship with traumatic sepsis remains unknown. The aim of our study was to evaluate whether plasma vanin-1 could be used for the early prediction of traumatic sepsis. In this three-stage prospective cohort study, severe trauma patients admitted from January 2015 to October 2018 at two hospitals were enrolled. Plasma vanin-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). The associations among variables and traumatic sepsis were identified by logistic regression models and the receiver operating characteristic (ROC) curve was analyzed to evaluate the diagnostic efficiency. A total of 426 trauma patients (22 in the discovery cohort, 283 in the internal test cohort, and 121 in the external validation cohort) and 16 healthy volunteers were recruited. The plasma vanin-1 of trauma patients was significantly higher than that of healthy volunteers (P < 0.05). Patients with sepsis had higher plasma vanin-1 than patients without sepsis in the discovery trauma cohort (P < 0.05). In the internal test cohort, plasma vanin-1 at day 1 after trauma was significantly associated with the incidence of sepsis (OR = 3.92, 95% CI 2.68–5.72, P = 1.62 × 10−12). As a predictive biomarker, vanin-1 afforded a better area under the curve (AUC) (0.82, 95% CI 0.77–0.87) than C-reaction protein (CRP) (0.62, 95% CI 0.56–0.68, P < 0.0001), procalcitonin (PCT) (0.66, 95% CI 0.60–0.71, P < 0.0001), and Acute Physiology and Chronic Health Evaluation II (APACHE II) (0.71, 95% CI 0.65–0.76, P = 6.70 × 10−3). The relevance was further validated in the external validation cohort (OR = 4.26, 95% CI 2.22–8.17, P = 1.28 × 10−5), with an AUC of 0.83 (95% CI 0.75–0.89). Vanin-1 could also improve the diagnostic efficiency of APACHE II (AUC = 0.85). Our study demonstrated that plasma vanin-1 increased among trauma patients and was independently associated with the risk of sepsis. Vanin-1 might be a potential biomarker for the early prediction of traumatic sepsis. Clinicaltrials.gov Identifier, NCT01713205. The online version contains supplementary material available at 10.1007/s40121-021-00414-w.
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DOI：
10.1136/injuryprev-2015-041616
发表时间：
2016-02
期刊：
Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention
影响因子：
--
作者：
Haagsma JA;Graetz N;Bolliger I;Naghavi M;Higashi H;Mullany EC;Abera SF;Abraham JP;Adofo K;Alsharif U;Ameh EA;Ammar W;Antonio CA;Barrero LH;Bekele T;Bose D;Brazinova A;Catalá-López F;Dandona L;Dandona R;Dargan PI;De Leo D;Degenhardt L;Derrett S;Dharmaratne SD;Driscoll TR;Duan L;Petrovich Ermakov S;Farzadfar F;Feigin VL;Franklin RC;Gabbe B;Gosselin RA;Hafezi-Nejad N;Hamadeh RR;Hijar M;Hu G;Jayaraman SP;Jiang G;Khader YS;Khan EA;Krishnaswami S;Kulkarni C;Lecky FE;Leung R;Lunevicius R;Lyons RA;Majdan M;Mason-Jones AJ;Matzopoulos R;Meaney PA;Mekonnen W;Miller TR;Mock CN;Norman RE;Orozco R;Polinder S;Pourmalek F;Rahimi-Movaghar V;Refaat A;Rojas-Rueda D;Roy N;Schwebel DC;Shaheen A;Shahraz S;Skirbekk V;Søreide K;Soshnikov S;Stein DJ;Sykes BL;Tabb KM;Temesgen AM;Tenkorang EY;Theadom AM;Tran BX;Vasankari TJ;Vavilala MS;Vlassov VV;Woldeyohannes SM;Yip P;Yonemoto N;Younis MZ;Yu C;Murray CJ;Vos T
通讯作者：
Vos T
影响因子：
4.9
作者：
Pouyet, Laurent;Roisin-Bouffay, Celine;Galland, Franck
通讯作者：
Galland, Franck
影响因子：
7.3
作者：
Vourc'h M;Roquilly A;Asehnoune K
通讯作者：
Asehnoune K
影响因子：
8.8
作者：
Chung, Kuei-Pin;Chen, Guan-Yuan;Yu, Chong-Jen
通讯作者：
Yu, Chong-Jen
影响因子：
3.9
作者：
Naquet, Philippe;Pitari, Giuseppina;Galland, Franck
通讯作者：
Galland, Franck