Lack of evidence for intermolecular epistatic interactions between adiponectin and resistin gene polymorphisms in Malaysian male subjects.
Lack of evidence for intermolecular epistatic interactions between adiponectin and resistin gene polymorphisms in Malaysian male subjects.
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DOI：
10.1590/s1415-47572011005000058
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发表时间：
2012-01
影响因子：
2.1
通讯作者：
Muniandy S
中科院分区：
文献类型：
--
作者：
Lau CH;Muniandy S
上位性（基因-基因相互作用）是复杂性状遗传结构中普遍存在的组成部分，例如对常见人类疾病的易感性。鉴于循环脂联素和抵抗素水平之间存在强负相关性，ADIPOQ（SNP+45T > G、SNP+276G > T、SNP+639T > C和SNP+1212A > G）和RETN（SNP-420C > G和SNP+299G > A）基因多态性之间潜在的分子间上位相互作用在2型糖尿病（T2DM）和代谢综合征的遗传风险中（MS）进行了评估。还检查了 ADIPOQ 和 RETN 基因对其脂肪因子水平的潜在相互影响。 RETN 基因座的 SNP-420C > G 的罕见纯合基因型（风险等位基因）倾向于与 ADIPOQ 基因座的 SNP+639T > C 和 SNP+1212A > G 的常见纯合基因型（保护性等位基因）共同遗传。尽管 ADIPOQ 和 RETN 基因之间存在密切的结构关系，但没有证据表明这些基因之间存在分子间上位相互作用。 ADIPOQ 和 RETN 基因对其脂肪因子水平也没有相互影响，即 ADIPOQ 不影响抵抗素水平，RETN 也不影响脂联素水平。 ADIPOQ 基因对 RETN 表达的可能影响值得进一步研究。
Epistasis (gene-gene interaction) is a ubiquitous component of the genetic architecture of complex traits such as susceptibility to common human diseases. Given the strong negative correlation between circulating adiponectin and resistin levels, the potential intermolecular epistatic interactions between ADIPOQ (SNP+45T > G, SNP+276G > T, SNP+639T > C and SNP+1212A > G) and RETN (SNP-420C > G and SNP+299G > A) gene polymorphisms in the genetic risk underlying type 2 diabetes (T2DM) and metabolic syndrome (MS) were assessed. The potential mutual influence of the ADIPOQ and RETN genes on their adipokine levels was also examined. The rare homozygous genotype (risk alleles) of SNP-420C > G at the RETN locus tended to be co-inherited together with the common homozygous genotypes (protective alleles) of SNP+639T > C and SNP+1212A > G at the ADIPOQ locus. Despite the close structural relationship between the ADIPOQ and RETN genes, there was no evidence of an intermolecular epistatic interaction between these genes. There was also no reciprocal effect of the ADIPOQ and RETN genes on their adipokine levels, i.e., ADIPOQ did not affect resistin levels nor did RETN affect adiponectin levels. The possible influence of the ADIPOQ gene on RETN expression warrants further investigation.
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影响因子：
7.7
作者：
Ochi, Masaak;Osawa, Haruhiko;Makino, Hideichi
通讯作者：
Makino, Hideichi
影响因子：
5.3
作者：
Heid, Iris M.;Henneman, Peter;Hicks, Andrew;Coassin, Stefan;Winkler, Thomas;Aulchenko, Yurii S.;Fuchsberger, Christian;Song, Kijoung;Hivert, Marie-France;Waterworth, Dawn M.;Timpson, Nicholas J.;Richards, J. Brent;Perry, John R. B.;Tanaka, Toshiko;Amin, Najaf;Kollerits, Barbara;Pichler, Irene;Oostra, Ben A.;Thorand, Barbara;Frants, Rune R.;Illig, Thomas;Dupuis, Josee;Glaser, Beate;Spector, Tim;Guralnik, Jack;Egan, Josephine M.;Florez, Jose C.;Evans, David M.;Soranzo, Nicole;Bandinelli, Stefania;Carlson, Olga D.;Frayling, Timothy M.;Burling, Keith;Smith, George Davey;Mooser, Vincent;Ferrucci, Luigi;Meigs, James B.;Vollenweider, Peter;van Dijk, Ko Willems;Pramstaller, Peter;Kronenberg, Florian;van Duijn, Cornelia M.
通讯作者：
van Duijn, Cornelia M.
影响因子：
56.9
作者：
Patel, SD;Rajala, MW;Shapiro, L
通讯作者：
Shapiro, L
影响因子：
1.8
作者：
Moore, JH
通讯作者：
Moore, JH
影响因子：
6.9
作者：
Ling, Hua;Waterworth, Dawn M.;Stirnadel, Heide A.;Pollin, Toni I.;Barter, Philip J.;Kesaniemi, Y. Antero;Mahley, Robert W.;McPherson, Ruth;Waeber, Gerard;Bersot, Thomas P.;Cohen, Jonathan C.;Grundy, Scott M.;Mooser, Vincent E.;Mitchell, Braxton D.
通讯作者：
Mitchell, Braxton D.