Autoantibodies to alpha-synuclein in inherited Parkinson's disease.
Autoantibodies to alpha-synuclein in inherited Parkinson's disease.
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DOI：
10.1111/j.1471-4159.2006.04365.x
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发表时间：
2007-05
影响因子：
4.7
通讯作者：
Buchman VL
中科院分区：
文献类型：
--
作者：
Papachroni KK;Ninkina N;Papapanagiotou A;Hadjigeorgiou GM;Xiromerisiou G;Papadimitriou A;Kalofoutis A;Buchman VL
帕金森病（PD）的神经退行性变伴随着受影响大脑区域的局部免疫反应。已经确定α-突触核蛋白直接参与PD的发病机制。疾病的发展通常与这种蛋白质的表达和细胞区室化的变化有关;此外，其寡聚体或原纤维通常释放到患者的CSF和血浆中。聚集的α-突触核蛋白可以触发小胶质细胞的活化;然而，尚未评估其诱导产生特异性自身抗体（AAb）的能力。在这项研究中，我们研究了存在的AAb对突触核蛋白家族成员在外周血中的PD患者和对照个体的血清。抗β-突触核蛋白或γ-突触核蛋白AAb的存在与PD无关。在65%的受试患者中检测到抗α-突触核蛋白的多表位AAb，其存在与疾病的遗传模式密切相关，但与其他疾病相关因素无关。散发型PD患者研究组中AAb的出现频率与对照组中的频率无显著差异，但家族性PD患者中抗α-突触核蛋白AAb阳性的比例非常高（90%）。我们假设这些AAb可能参与遗传性PD的发病机制。
Neurodegeneration in Parkinson’s disease (PD) is accompanied by a local immune reaction in the affected brain regions. It is well established that α-synuclein is directly implicated in the pathogenesis of PD. Development of the disease is often associated with changes of expression and cellular compartmentalisation of this protein; moreover, its oligomers or protofibrils are often released to the CSF and plasma of patients. Aggregated α-synuclein can trigger the activation of microglia; however, its capacity to induce production of specific autoantibodies (AAb) has not been assessed. In this study, we examined the presence of AAb against synuclein family members in the peripheral blood serum of PD patients and control individuals. Presence of AAb against β-synuclein or γ-synuclein showed no association with PD. Multi-epitopic AAb against α-synuclein were detected in 65% of all patients tested and their presence strongly correlated with an inherited mode of the disease but not with other disease-related factors. The frequency of the presence of AAb in the studied group of patients with sporadic form of PD was not significantly different from the frequency in the control group but very high proportion (90%) of patients with familial form of the disease were positive for AAb against α-synuclein. We hypothesise that these AAb could be involved in pathogenesis of the inherited form of PD.
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DOI：
10.1073/pnas.0400569101
发表时间：
2004-06-22
影响因子：
11.1
作者：
Benner, EJ;Mosley, RL;Gendelman, HE
通讯作者：
Gendelman, HE
影响因子：
64.8
作者：
Janus, C;Pearson, J;Westaway, D
通讯作者：
Westaway, D
影响因子：
4.4
作者：
Shavali, S;Combs, C;Ebadi, M
通讯作者：
Ebadi, M
影响因子：
--
作者：
Chen, SD;Le, WDD;Appel, SH
通讯作者：
Appel, SH
影响因子：
2.9
作者：
DEFAZIO, G;DALTOSO, R;LEON, A
通讯作者：
LEON, A