Microbiota's Role in Diet-Driven Alterations in Food Intake: Satiety, Energy Balance, and Reward.
Microbiota's Role in Diet-Driven Alterations in Food Intake: Satiety, Energy Balance, and Reward.
复制标题
微生物区系在饮食驱动的食物摄入量变化中的作用：饱足感、能量平衡和奖励。
DOI：
10.3390/nu13093067
复制
发表时间：
2021-08-31
期刊：
影响因子：
5.9
通讯作者：
de La Serre CB
中科院分区：
文献类型：
--
作者：
Rautmann AW;de La Serre CB
肠道微生物群在调节宿主生理和行为，特别是摄食行为和能量稳态方面发挥着关键作用。越来越多的证据表明肠道微生物群在肥胖病因学中发挥着重要作用。在人类和啮齿动物研究中，肥胖和高能量喂养最一致地发现与细菌多样性减少、主要门相对丰度变化和促炎产物增加有关。与饮食相关的微生物组成的改变与体重增加、肥胖和摄入行为的变化有关。微生物群通过多种途径影响食物摄入。本综述讨论了这些途径，包括外周机制，例如肠道饱腹感肽释放的调节以及沿着迷走神经的瘦素和胆囊收缩素信号传导的改变，以及中枢机制，例如下丘脑神经炎症的调节和奖励信号传导的改变。目前大多数研究的重点是确定微生物组在肥胖发展中的作用，并利用微生物组控制来防止饮食引起的食物摄入量增加。需要更多的研究来确定长期高能量饮食和肥胖后的微生物组调控是否可以减少摄入量并促进有意义的减肥。
The gut microbiota plays a key role in modulating host physiology and behavior, particularly feeding behavior and energy homeostasis. There is accumulating evidence demonstrating a role for gut microbiota in the etiology of obesity. In human and rodent studies, obesity and high-energy feeding are most consistently found to be associated with decreased bacterial diversity, changes in main phyla relative abundances and increased presence of pro-inflammatory products. Diet-associated alterations in microbiome composition are linked with weight gain, adiposity, and changes in ingestive behavior. There are multiple pathways through which the microbiome influences food intake. This review discusses these pathways, including peripheral mechanisms such as the regulation of gut satiety peptide release and alterations in leptin and cholecystokinin signaling along the vagus nerve, as well as central mechanisms, such as the modulation of hypothalamic neuroinflammation and alterations in reward signaling. Most research currently focuses on determining the role of the microbiome in the development of obesity and using microbiome manipulation to prevent diet-induced increase in food intake. More studies are necessary to determine whether microbiome manipulation after prolonged energy-dense diet exposure and obesity can reduce intake and promote meaningful weight loss.
登录
查看更多内容
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
DOI：
10.1152/ajpgi.00098.2010
发表时间：
2010-08-01
影响因子：
4.5
作者：
de La Serre, Claire Barbier;Ellis, Collin L.;Raybould, Helen E.
通讯作者：
Raybould, Helen E.
DOI：
10.1152/ajpgi.1998.275.6.g1415
发表时间：
1998-12-01
影响因子：
4.5
作者：
Cherbut, C;Ferrier, L;Galimiche, JP
通讯作者：
Galimiche, JP
影响因子：
17.1
作者：
Blumberg R;Powrie F
通讯作者：
Powrie F
L细胞转录组的微生物调节。
影响因子：
4.6
作者：
Arora T;Akrami R;Pais R;Bergqvist L;Johansson BR;Schwartz TW;Reimann F;Gribble FM;Bäckhed F
通讯作者：
Bäckhed F