Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus.
Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus.
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二甲双胍抑制下丘脑的食物摄入和神经肽 Y 基因表达
DOI：
10.3969/j.issn.1673-5374.2013.25.009
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发表时间：
2013-09-05
影响因子：
6.1
通讯作者：
Zhao Z
中科院分区：
文献类型：
--
作者：
Duan Y;Zhang R;Zhang M;Sun L;Dong S;Wang G;Zhang J;Zhao Z
二甲双胍可以减少食物摄入量和体重，但二甲双胍的厌食作用仍然知之甚少。在这项研究中，Sprague-Dawley大鼠单次脑室内给予二甲双胍和化合物C，以更广泛地研究二甲双胍对摄食的调节作用并探索可能的机制。结果显示二甲双胍中心给药显著降低了摄食量和体重增量，特别是在4小时后。二甲双胍给药后4小时，还观察到下丘脑神经肽Y表达减少和AMP活化蛋白激酶磷酸化诱导，这可以被化合物C逆转，化合物C是一种常用的AMP活化蛋白激酶拮抗剂。此外，二甲双胍还通过降低血浆低密度脂蛋白改善脂质代谢。我们的研究结果表明，在正常生理条件下，二甲双胍对食欲的中枢调节与神经肽Y基因表达的减少有关，AMP活化蛋白激酶的激活可能只是对二甲双胍促食欲作用的反应。
Metformin may reduce food intake and body weight, but the anorexigenic effects of metformin are still poorly understood. In this study, Sprague-Dawley rats were administered a single intracere-broventricular dose of metformin and compound C, in a broader attempt to investigate the regula-tory effects of metformin on food intake and to explore the possible mechanism. Results showed that central administration of metformin significantly reduced food intake and body weight gain, par-ticularly after 4 hours. A reduction of neuropeptide Y expression and induction of AMP-activated protein kinase phosphorylation in the hypothalamus were also observed 4 hours after metformin administration, which could be reversed by compound C, a commonly-used antagonist of AMP-activated protein kinase. Furthermore, metformin also improved lipid metabolism by reducing plasma low-density lipoprotein. Our findings suggest that under normal physiological conditions, central regulation of appetite by metformin is related to a decrease in neuropeptide Y gene expres-sion, and that the activation of AMP-activated protein kinase may simply be a response to the anorexigenic effect of metformin.
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影响因子：
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作者：
Hutcheson R;Rocic P
通讯作者：
Rocic P
影响因子：
7.7
作者：
Kim, YW;Kim, JY;Moon, KH
通讯作者：
Moon, KH
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通讯作者：
Zukowska, Zofia
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影响因子：
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作者：
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通讯作者：
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