CSF profile in primary progressive multiple sclerosis: Re-exploring the basics.
CSF profile in primary progressive multiple sclerosis: Re-exploring the basics.
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DOI：
10.1371/journal.pone.0182647
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Tumani H
中科院分区：
文献类型：
--
作者：
Abdelhak A;Hottenrott T;Mayer C;Hintereder G;Zettl UK;Stich O;Tumani H
本研究的目的是报道原发性进行性多发性硬化症（PPMS）患者的基本脑脊液（CSF）特征。收集了德国四所大学医院254名PPMS患者的脑脊液分析结果。观察脑脊液常规参数及鞘内免疫球蛋白合成指标。我们评估了在腰椎穿刺时和疾病过程中各种CSF参数与扩展残疾状态量表（EDSS）之间可能的相关性。脑脊液中细胞计数和白蛋白浓度均未偏离正常值。29.6%的患者csf -血清白蛋白商（QALB）升高，91.1%的患者检测到鞘内免疫球蛋白G （IgG）寡克隆带（ocb）。根据EDSS评估，csf -乳酸水平以及局部IgM-和iga合成与年度疾病进展率相关。我们对254名PPMS患者进行了迄今为止最大和最详细的脑脊液生物标志物分析。如前所述，ocb是鞘内IgG合成最敏感的标志物。csf -乳酸浓度与进展率呈正相关，这可能表明线粒体功能障碍在PPMS中起相关作用。鞘内产生的IgM和IgA与疾病进展之间的负相关可能表明它们迄今未被探索的保护作用。
The aim of this study was to report the basic cerebrospinal fluid (CSF) profile in patients with primary progressive multiple sclerosis (PPMS). The results of CSF analysis from 254 patients with PPMS were collected at four university hospitals in Germany. Routine CSF parameters and different indices of intrathecal immunoglobulin synthesis were evaluated. We assessed possible correlations between the various CSF parameters and the expanded disability status scale (EDSS) both at the time of lumbar puncture and during the course of the disease. The median cell count and albumin concentration in the CSF did not deviate from normal values. The CSF-serum albumin-quotient (QALB) was elevated in 29.6% of the patients, while intrathecal immunoglobulin G (IgG) oligoclonal bands (OCBs) were detected in 91.1% of the patients. CSF-lactate levels as well as local IgM- and IgA-synthesis were correlated with the yearly disease progression rate, as assessed by EDSS. We present the results of the hitherto largest and most detailed CSF biomarker profile in a cohort of 254 patients with PPMS. As reported previously, OCBs are the most sensitive marker for intrathecal IgG synthesis. CSF-lactate concentrations are positively correlated with the progression rate, which might suggest that mitochondrial dysfunction plays a relevant role in PPMS. The negative correlation between intrathecally produced IgM and IgA and disease progression may indicate their hitherto unexplored protective role.
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影响因子：
3.7
作者：
Brettschneider J;Tumani H;Kiechle U;Muche R;Richards G;Lehmensiek V;Ludolph AC;Otto M
通讯作者：
Otto M
影响因子：
3.5
作者：
Lunding, J;Midgard, R;Vedeler, CA
通讯作者：
Vedeler, CA
影响因子：
7.3
作者：
Hottenrott T;Dersch R;Berger B;Rauer S;Eckenweiler M;Huzly D;Stich O
通讯作者：
Stich O
影响因子：
7.3
作者：
Hottenrott T;Dersch R;Berger B;Rauer S;Huzly D;Stich O
通讯作者：
Stich O
影响因子：
3.7
作者：
Romme Christensen J;Börnsen L;Ratzer R;Piehl F;Khademi M;Olsson T;Sørensen PS;Sellebjerg F
通讯作者：
Sellebjerg F