Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis.
Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis.
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DOI：
10.1371/journal.pone.0043934
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Basu S
中科院分区：
文献类型：
--
作者：
Lu K;Chakroborty D;Sarkar C;Lu T;Xie Z;Liu Z;Basu S
Triphala churna (THL) is a combination of three fruits that has been used for many years in India for the treatment of various diseases. There are now reports which indicate that THL can inhibit growth of malignant tumors in animals. However, the mechanisms by which THL mediates its anti-tumor actions are still being explored. Because vascular endothelial growth factor-A (VEGF) induced angiogenesis plays a critical role in the pathogenesis of cancer, we therefore investigated whether tumor inhibitory effects of THL or its active constituents are through suppression of VEGF actions. We herein report that THL and chebulinic (CI) present in THL can significantly and specifically inhibit VEGF induced angiogenesis by suppressing VEGF receptor-2 (VEGFR-2) phosphorylation. These results are of clinical significance as these inexpensive and non-toxic natural products can be used for the prevention and treatment of diseases where VEGF induced angiogenesis has an important role.
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Triphala通过诱导凋亡抑制胰腺肿瘤细胞的体外和体内异种移植生长。
影响因子：
3.8
作者：
Shi, Yan;Sahu, Ravi P.;Srivastava, Sanjay K.
通讯作者：
Srivastava, Sanjay K.
DOI：
10.3233/jad-2009-1135
发表时间：
2009
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Ferruzzi MG;Lobo JK;Janle EM;Cooper B;Simon JE;Wu QL;Welch C;Ho L;Weaver C;Pasinetti GM
通讯作者：
Pasinetti GM
影响因子：
9.8
作者：
Hussain, S.;Slevin, M.;Gaffney, J.
通讯作者：
Gaffney, J.
DOI：
10.1161/atvbaha.108.179663
发表时间：
2009-06-01
影响因子：
8.7
作者：
Ferrara, Napoleone
通讯作者：
Ferrara, Napoleone
影响因子：
4.6
作者：
Mulder, Karen;Scarfe, Andrew;Spratlin, Jennifer
通讯作者：
Spratlin, Jennifer