Roles of the Coding and Noncoding Regions of Rift Valley Fever Virus RNA Genome Segments in Viral RNA Packaging
Roles of the Coding and Noncoding Regions of Rift Valley Fever Virus RNA Genome Segments in Viral RNA Packaging
复制标题
裂谷热病毒 RNA 基因组片段的编码和非编码区域在病毒 RNA 包装中的作用
DOI：
10.1128/jvi.06700-11
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发表时间：
2012
影响因子：
5.4
通讯作者：
S. Makino
中科院分区：
文献类型：
--
作者：
S. Murakami;Kaori Terasaki;Krishna Shankara Narayanan;S. Makino
我们鉴定了裂谷热病毒RNA基因组片段L、M和S包装中涉及的RNA元件。每个RNA片段的5′端25个核苷酸具有相同的RNA包装能力，并携带RNA包装信号，该信号与RNA复制信号重叠。只有缺失突变体的L RNA，而不是全长的L RNA，被有效地包装，这意味着可能需要的RNA压缩的L RNA包装。
ABSTRACT We characterized the RNA elements involved in the packaging of Rift Valley fever virus RNA genome segments, L, M, and S. The 5′-terminal 25 nucleotides of each RNA segment were equally competent for RNA packaging and carried an RNA packaging signal, which overlapped with the RNA replication signal. Only the deletion mutants of L RNA, but not full-length L RNA, were efficiently packaged, implying the possible requirement of RNA compaction for L RNA packaging.
影响因子：
3.7
作者：
Gauliard, Nicolas;Billecocq, Agnes;Bouloy, Michele
通讯作者：
Bouloy, Michele