Pharmacogenetic approaches to the treatment of alcohol addiction.
Pharmacogenetic approaches to the treatment of alcohol addiction.
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DOI：
10.1038/nrn3110
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发表时间：
2011-10-20
影响因子：
34.7
通讯作者：
O'Brien, Charles P.
中科院分区：
文献类型：
--
作者：
Heilig, Markus;Goldman, David;Berrettini, Wade;O'Brien, Charles P.
成瘾性疾病是部分可遗传的、慢性的、复发性疾病，造成巨大的疾病负担。目前可用的成瘾药物疗法仅取得了一定的成功，在科学界之外仍然受到相当大的怀疑，并且尚未被广泛采用作为治疗方法。需要更有效的医疗方法来改变成瘾治疗并解决当前未满足的医疗需求。酗酒研究的新证据表明，没有任何单一进展可以从根本上改变治疗结果。相反，对阿片类药物、促肾上腺皮质激素释放因子、GABA 和血清素系统的研究表明，治疗结果的不断进步将源于对酒精成瘾患者遗传异质性的更好理解以及个性化治疗的开发。
Addictive disorders are partly heritable, chronic, relapsing conditions that account for a tremendous disease burden. Currently available addiction pharmacotherapies are only moderately successful, continue to be viewed with considerable scepticism outside the scientific community and have not become widely adopted as treatments. More effective medical treatments are needed to transform addiction treatment and address currently unmet medical needs. Emerging evidence from alcoholism research suggests that no single advance can be expected to fundamentally change treatment outcomes. Rather, studies of opioid, corticotropin-releasing factor, GABA and serotonin systems suggest that incremental advances in treatment outcomes will result from an improved understanding of the genetic heterogeneity among patients with alcohol addiction, and the development of personalized treatments.
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影响因子：
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影响因子：
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