Randomized Trial of a High Protein, Partial Meal Replacement Program with or without Alternate Day Fasting: Similar Effects on Weight Loss, Retention Status, Nutritional, Metabolic, and Behavioral Outcomes.
Randomized Trial of a High Protein, Partial Meal Replacement Program with or without Alternate Day Fasting: Similar Effects on Weight Loss, Retention Status, Nutritional, Metabolic, and Behavioral Outcomes.
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DOI：
10.3390/nu10091145
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发表时间：
2018-08-23
期刊：
影响因子：
5.9
通讯作者：
Noakes M
中科院分区：
文献类型：
--
作者：
Bowen J;Brindal E;James-Martin G;Noakes M
高蛋白饮食、代餐和早期更大的体重减轻分别与更大的体重减轻有关。我们比较了每日能量限制（DER）的高蛋白膳食替代方案与提供更大能量限制并隔日禁食（ADF + DER；调整禁食和DER交替进行的日子加上1天/周的自由活动）的保留、体重减轻、生理、营养和行为指标。参与者随机分为ADF + DER组或DER组，为期16周（n = 162，年龄40±8岁，BMI 36±6 kg/m2 (Mean±SD)），外加8周体重维持。第16周时，ADF + DER组和DER组（NS组）体重变化分别为- 10.7±0.5 kg和- 11.2±0.6 kg。脂肪量、内脏脂肪组织和瘦肉质量在两种治疗之间也有相似的降低（p < 0.05）。体重减轻持续至24周（NS治疗）。空腹ldl -胆固醇、甘油三酯、胰岛素、hsCRP、葡萄糖和血压均有改善（p < 0.05；治疗后无症状）。转铁蛋白饱和度、铁蛋白、血清锌、叶酸和B12均有所改善（p < 0.05）。血浆硫胺素和维生素D水平下降，分别反映了碳水化合物摄入量减少和季节变化。对食物的渴望，生活质量和情绪的改善（治疗NS）。DER组能量、疲劳和疼痛改善稍多（p < 0.05）。这项研究支持在体重管理中使用含或不含ADF的高蛋白膳食替代方案。
Higher-protein diets, meal replacements, and greater early weight loss have separately been associated with greater weight loss. We compared a high-protein, meal replacement program with daily energy restriction (DER) to one which provided greater energy restriction adding alternate day fasting (ADF + DER; alternating days of modified-fasting and DER plus 1 ad libitum day/week) on retention, weight loss, physiological, nutritional, and behavioral markers. Participants were randomized to ADF + DER or DER for 16 weeks (n = 162, age 40 ± 8 years BMI 36 ± 6 kg/m2 (Mean ± SD)) plus 8 weeks weight maintenance. At week 16 weight change was −10.7 ± 0.5 kg and −11.2 ± 0.6 kg in ADF + DER and DER groups (treatment NS). Fat mass, visceral adipose tissue, and lean mass (p < 0.05) were similarly reduced between treatments. Weight loss was sustained to 24 weeks (treatment NS). Fasting LDL-cholesterol, triglycerides, insulin, hsCRP, glucose, and blood pressure all improved (p < 0.05; treatment NS). Transferrin saturation, ferritin, serum zinc, folate, and B12 improved (p < 0.05; treatment NS). Plasma thiamine and vitamin D levels decreased, reflecting lower carbohydrate intakes and seasonal changes, respectively. Food cravings, quality of life, and mood improved (treatment NS). Energy, fatigue, and pain improved slightly more in DER (p < 0.05). This study supports the use of higher protein, meal replacement programs with or without ADF in weight management.
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影响因子：
2.2
作者：
Alhamdan, B A;Garcia-Alvarez, A;Alzahrnai, A H;Karanxha, J;Stretchberry, D R;Contrera, K J;Utria, A F;Cheskin, L J
通讯作者：
Cheskin, L J
影响因子：
4.9
作者：
Aller, E. E. J. G.;Larsen, T. M.;van Baak, M. A.
通讯作者：
van Baak, M. A.
DOI：
10.11124/jbisrir-2016-003248
发表时间：
2018-02-01
期刊：
JBI database of systematic reviews and implementation reports
影响因子：
--
作者：
Harris, Leanne;Hamilton, Sharon;Ells, Louisa
通讯作者：
Ells, Louisa
影响因子：
3
作者：
MCHORNEY, CA;WARE, JE;RACZEK, AE
通讯作者：
RACZEK, AE
影响因子：
4.4
作者：
Hays, RD;Morales, LS
通讯作者：
Morales, LS