A barcode-free combinatorial screening platform for matrix metalloproteinase screening.

A barcode-free combinatorial screening platform for matrix metalloproteinase screening.
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DOI:
10.1021/ac504330x
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发表时间:
2015-02-03
影响因子:
7.4
通讯作者:
Wang, Tza-Huei
Wang, Tza-Huei
中科院分区:
化学1区
文献类型:
--
作者:
Rane, Tushar D.;Zec, Helena C.;Wang, Tza-Huei

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液滴微流体在组合筛选中的应用仍然难以捉摸,因为需要组合物识别的唯一条形码。本文提出了一种适合组合筛选应用的无条形码连续流液滴微流控平台。我们以基质金属蛋白酶活性筛选作为样本应用,展示了该平台的稳健和可重复功能。
Application of droplet microfluidics to combinatorial screening applications remains elusive because of the need for composition-identifying unique barcodes. Here we propose a barcode-free continuous flow droplet microfluidic platform to suit the requirements of combinatorial screening applications. We demonstrate robust and repeatable functioning of this platform with matrix metalloproteinase activity screening as a sample application.
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