Osteoporosis affects both post-yield microdamage accumulation and plasticity degradation in vertebra of ovariectomized rats
Osteoporosis affects both post-yield microdamage accumulation and plasticity degradation in vertebra of ovariectomized rats
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骨质疏松症影响去势大鼠椎骨的产后微损伤积累和可塑性退化
DOI：
10.1007/s10409-017-0643-1
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发表时间：
2017-03
影响因子：
3.5
通讯作者：
Leng Huijie
中科院分区：
文献类型：
--
作者：
Li Siwei;Niu Guodong;Dong Neil X.;Wang Xiaodu;Liu Zhongjun;Song Chunli;Leng Huijie
绝经后妇女雌激素戒断会增加椎骨的骨丢失和骨脆性。骨质疏松症引起的骨丢失不仅降低了骨密度，而且改变了骨质量，这可以通过骨屈服后行为来综合反映。本研究的目的是提供一些信息，如何骨质疏松症引起的雌激素耗竭可能会影响的演变后屈服的微损伤积累和塑性变形的椎体。本研究还试图揭示雌激素缺乏导致骨质疏松症增加骨折风险的部分机制。采用大鼠双侧卵巢切除（OVX）模型，诱导骨质疏松症。为椎骨测试开发了渐进循环压缩载荷，以阐明屈服后行为。比较假手术和OVX后5周（ovx5w和sham5w组）和35周（ovx35w和sham35w组）饲养的大鼠的BMD、骨体积分数、刚度退化和塑性变形演变。结果表明，椎体骨丢失越多，椎体刚度越低，塑性变形越大。因此，骨质疏松可能通过微损伤累积和塑性变形降解增加椎体骨折的风险。
Estrogen withdrawal in postmenopausal women increases bone loss and bone fragility in the vertebra. Bone loss with osteoporosis not only reduces bone mineral density (BMD), but actually alters bone quality, which can be comprehensively represented by bone post-yield behaviors. This study aimed to provide some information as to how osteoporosis induced by estrogen depletion could influence the evolution of post-yield microdamage accumulation and plastic deformation in vertebral bodies. This study also tried to reveal the part of the mechanisms of how estrogen deficiency-induced osteoporosis would increase the bone fracture risk. A rat bilateral ovariectomy (OVX) model was used to induce osteoporosis. Progressive cyclic compression loading was developed for vertebra testing to elucidate the post-yield behaviors. BMD, bone volume fraction, stiffness degradation, and plastic deformation evolution were compared among rats raised for 5 weeks (ovx5w and sham5w groups) and 35 weeks (ovx35w and sham35w groups) after sham surgery and OVX. The results showed that a higher bone loss in vertebral bodies corresponded to lower stiffness and higher plastic deformation. Thus, osteoporosis could increase the vertebral fracture risk probably through microdamage accumulation and plastic deforming degradation.
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影响因子：
4.2
作者：
P. Geusens;T. van Geel;J. V. D. van den Bergh
通讯作者：
P. Geusens;T. van Geel;J. V. D. van den Bergh
股骨头缺血性坏死松质骨的显微结构与性能
影响因子：
3.5
作者：
Dai, Ruchun;Wang, Peng;Yao, Xuefeng;Yeh, Hsien Yang
通讯作者：
Yeh, Hsien Yang
影响因子：
9.8
作者：
A. Licata
通讯作者：
A. Licata
影响因子：
4.1
作者：
MORI, S;BURR, DB
通讯作者：
BURR, DB
DOI：
10.2106/00004623-197658010-00015
发表时间：
1976-01-01
影响因子：
5.3
作者：
BURSTEIN, AH;REILLY, DT;MARTENS, M
通讯作者：
MARTENS, M