Case Report: Discovery a Novel SARS-CoV-2 Variant in a Six-Months Long-Term Swab Positive Female Suffering From Non-Hodgkin Lymphoma.
Case Report: Discovery a Novel SARS-CoV-2 Variant in a Six-Months Long-Term Swab Positive Female Suffering From Non-Hodgkin Lymphoma.
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DOI：
10.3389/fonc.2021.705948
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发表时间：
2021
影响因子：
4.7
通讯作者：
Castaldo G
中科院分区：
文献类型：
--
作者：
Capoluongo E;Nardelli C;Esposito MV;Buonomo AR;Gelzo M;Pinchera B;Zappulo E;Viceconte G;Portella G;Setaro M;Gentile I;Castaldo G
我们报告了一名患有非霍奇金淋巴瘤的妇女的病例，她在SARS-CoV-2的分子检测中保持阳性6个月：尽管没有血清转换，但她从未经历过严重的COVID-19。由CleaningsSARS-CoV-2 Research and Surveillance NGS Panel（PARAGON GENOMICS，海沃德，美国）进行SARS-CoV-2全基因组分析。我们在SARS-CoV-2基因组中发现了22个突变和一个新的有害ORF3a移码c.766_769del，对应于一个独特的新谱系。据报道，受这种移码变体影响的区域在确定SARS-CoV-2免疫原性方面很重要。患者的免疫表型显示缺乏B淋巴细胞和显著降低的T细胞计数。仅在用超免疫血浆治疗后，她的拭子结果才最终变为阴性。我们的研究结果可能有助于免疫缺陷患者的管理，特别是当存在可能改变病毒免疫反应的新变体时。
We report the case of a woman with non-Hodgkin lymphoma who remained positive on the molecular assay for SARS-CoV-2 for six months: she has never experienced a severe form of COVID-19 although in absence of seroconversion. The whole SARS-CoV-2 genome analysis was performed by the CleanPlex SARS-CoV-2 Research and Surveillance NGS Panel (PARAGON GENOMICS, Hayward, USA). We found twenty-two mutations in SARS-CoV-2 genome and a novel deleterious ORF3a frameshift c.766_769del corresponding to a unique and novel lineage. The region affected by this frameshift variant is reported as being important in determining SARS-CoV-2 immunogenicity. Patient’s immunophenotype showed the absence of B lymphocytes and significantly reduced T-cell count. Only after the treatment with hyperimmune plasma she finally became negative on the swab. Our findings could be helpful in the management of patients with immunodeficiency, particularly when novel variants, potentially altering the virus immune response, are present.
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DOI：
10.3390/diagnostics11020288
发表时间：
2021-02-12
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Zollo M;Ferrucci V;Izzo B;Quarantelli F;Domenico CD;Comegna M;Paolillo C;Amato F;Siciliano R;Castaldo G;Capoluongo E
通讯作者：
Capoluongo E
影响因子：
4.4
作者：
Hassan, Sk. Sarif;Choudhury, Pabitra Pal;Jana, Siddhartha Sankar
通讯作者：
Jana, Siddhartha Sankar
影响因子：
4.6
作者：
Nguyen TT;Pathirana PN;Nguyen T;Nguyen QVH;Bhatti A;Nguyen DC;Nguyen DT;Nguyen ND;Creighton D;Abdelrazek M
通讯作者：
Abdelrazek M
DOI：
10.3390/ijerph18041626
发表时间：
2021-02-08
影响因子：
--
作者：
Mehmood I;Ijaz M;Ahmad S;Ahmed T;Bari A;Abro A;Allemailem KS;Almatroudi A;Tahir Ul Qamar M
通讯作者：
Tahir Ul Qamar M
影响因子：
6.1
作者：
Cacciapuoti, Sara;De Rosa, Annunziata;Parrella, Roberto
通讯作者：
Parrella, Roberto