Endometriosis Is Undervalued: A Call to Action.
Endometriosis Is Undervalued: A Call to Action.
复制标题
DOI：
10.3389/fgwh.2022.902371
复制
发表时间：
2022
影响因子：
--
通讯作者：
Clarke, Jennifer
中科院分区：
文献类型：
--
作者：
Ellis, Katherine;Munro, Deborah;Clarke, Jennifer
子宫内膜异位症是一种炎症性慢性疼痛，由子宫外生长的子宫组织引起，全球至少有11%的女性（以及出生时指定为女性的人）受到影响。这种状况给这些妇女和整个社会造成了沉重的负担。虽然子宫内膜异位症是在160多年前首次发现的，但仍然存在大量的知识空白，包括对疾病病因的确认。子宫内膜异位症的研究资金是有限的，来自美国国立卫生研究院（NIH）等机构的资金仅占2022年健康预算的0.038%，仅在美国就有650万女性受到影响，全球超过1.9亿。一个主要问题是子宫内膜异位症的诊断经常被延迟，因为需要手术来组织学确认诊断。这种延迟增加了症状强度、中枢和外周致敏的风险以及患者及其国家的疾病成本。目前保守治疗假定子宫内膜异位症疼痛管理和节育。这两种方法都有缺陷，对于减少患者痛苦或提高工作能力完全无效，并且都不能解决严重的不孕问题或某些癌症的高风险。子宫内膜异位症的研究值得资金和关注，因为它的患病率、影响和经济成本都很高。这笔资金可以通过引入侵入性更小、更及时的诊断和治疗方法来改善患者的预后，包括新型生物标志物、纳米医学和微生物组改变等选择。
Endometriosis is an inflammatory chronic pain condition caused by uterine tissue growing outside of the uterus that afflicts at least 11% of women (and people assigned female at birth) worldwide. This condition results in a substantial burden to these women, and society at large. Although endometriosis was first identified over 160 years ago, substantial knowledge gaps remain, including confirmation of the disease's etiology. Research funding for endometriosis is limited, with funding from bodies like the National Institutes of Health (NIH) constituting only 0.038% of the 2022 health budget—for a condition that affects 6.5 million women in the US alone and over 190 million worldwide. A major issue is that diagnosis of endometriosis is frequently delayed because surgery is required to histologically confirm the diagnosis. This delay increases symptom intensity, the risk of central and peripheral sensitization and the costs of the disease for the patient and their nation. Current conservative treatments of presumed endometriosis are pain management and birth control. Both of these methods are flawed and can be entirely ineffective for the reduction of patient suffering or improving ability to work, and neither addresses the severe infertility issues or higher risk of certain cancers. Endometriosis research deserves the funding and attention that befits a disease with its substantial prevalence, effects, and economic costs. This funding could improve patient outcomes by introducing less invasive and more timely methods for diagnosis and treatment, including options such as novel biomarkers, nanomedicine, and microbiome alterations.
登录
查看更多内容
影响因子：
2.5
作者：
Ek, Malin;Roth, Bodil;Ohlsson, Bodil
通讯作者：
Ohlsson, Bodil
DOI：
10.1016/j.bpobgyn.2004.01.003
发表时间：
2004-04-01
影响因子：
5.5
作者：
Ballweg, ML
通讯作者：
Ballweg, ML
肠道微生物群衍生的短链脂肪酸可防止子宫内膜异位症的进展。
影响因子：
4.4
作者：
Chadchan SB;Popli P;Ambati CR;Tycksen E;Han SJ;Bulun SE;Putluri N;Biest SW;Kommagani R
通讯作者：
Kommagani R
DOI：
10.1111/ajo.13458
发表时间：
2021-11-22
影响因子：
1.7
作者：
Armour, Mike;Ciccia, Donna;Wardle, Jon
通讯作者：
Wardle, Jon
影响因子：
2.5
作者：
Abd El-Kader, Azza Ibrahim;Gonied, Amina Saad;Mohamed, Sabah Lotfy
通讯作者：
Mohamed, Sabah Lotfy