Load-induced modulation of signal transduction networks.
Load-induced modulation of signal transduction networks.
复制标题
负载诱导的信号转导网络的调制。
DOI：
10.1126/scisignal.2002152
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发表时间：
2011-10-11
影响因子：
7.3
通讯作者：
Del Vecchio D
中科院分区：
文献类型：
--
作者：
Jiang P;Ventura AC;Sontag ED;Merajver SD;Ninfa AJ;Del Vecchio D
Biological signal transduction networks are commonly viewed as circuits that pass along information -- in the process amplifying, enhancing sensitivity, or performing other signal-processing tasks -- to transcriptional and other components. Here, we report on a “reverse-causality” phenomenon, which we call load-induced modulation. Employing a combination of analytical and experimental tools, we discovered that signal communication is modulated, in a surprising way, by downstream targets that receive the signal and, in doing so, apply a load. Specifically, we found that non-intuitive changes in response dynamics can occur for a covalent modification cycle when a load is applied. Loading can either increase or decrease the response time of a system, depending upon whether the cycle enzyme activities are saturated to their maximum or minimum values by the stimulatory effector (limit regime) or not (intermediate regime), respectively. The bandwidth, the range of frequency where the system can process information, decreased in the presence of loading, so that downstream targets participate in establishing a balance between noise-filtering capabilities and a circuit’s ability to process high-frequency stimulation. Nodes in a signaling network are not independent relay devices, but rather are modulated by their downstream targets. The presence of downstream partners that interact with enzymatically modified or unmodified signaling proteins changes the dynamics of signal transduction.
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