Systemic immune activation leads to neuroinflammation and sickness behavior in mice.
Systemic immune activation leads to neuroinflammation and sickness behavior in mice.
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DOI：
10.1155/2013/271359
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发表时间：
2013
影响因子：
4.6
通讯作者：
Nuydens R
中科院分区：
文献类型：
--
作者：
Biesmans S;Meert TF;Bouwknecht JA;Acton PD;Davoodi N;De Haes P;Kuijlaars J;Langlois X;Matthews LJ;Ver Donck L;Hellings N;Nuydens R
大量证据表明临床抑郁症和免疫功能改变之间存在关联。细菌脂多糖（LPS）的全身给药通常用于研究啮齿动物中炎症相关的行为变化。在这些实验中，我们测试了外周免疫激活导致小鼠神经炎症和抑郁样行为的假设。我们报告，全身注射LPS诱导转基因GFAP-luc小鼠星形胶质细胞活化，并增加野生型小鼠齿状回小胶质细胞标记物离子钙结合衔接分子1的免疫反应性。此外，LPS处理引起血清和脑中细胞因子水平的强烈但短暂的增加。除了研究LPS诱导的神经炎症外，我们还通过在一组行为范例中评估LPS治疗的小鼠来测试疾病是否可以与抑郁样行为分开。我们的行为数据表明，全身LPS管理引起疾病和轻度抑郁样行为。然而，由于重叠的时间过程和对抑郁相关行为本身的轻微影响，在本啮齿动物模型中不可能将疾病与抑郁样行为分开。
Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these experiments, we tested the hypothesis that peripheral immune activation leads to neuroinflammation and depressive-like behavior in mice. We report that systemic administration of LPS induced astrocyte activation in transgenic GFAP-luc mice and increased immunoreactivity against the microglial marker ionized calcium-binding adapter molecule 1 in the dentate gyrus of wild-type mice. Furthermore, LPS treatment caused a strong but transient increase in cytokine levels in the serum and brain. In addition to studying LPS-induced neuroinflammation, we tested whether sickness could be separated from depressive-like behavior by evaluating LPS-treated mice in a panel of behavioral paradigms. Our behavioral data indicate that systemic LPS administration caused sickness and mild depressive-like behavior. However, due to the overlapping time course and mild effects on depression-related behavior per se, it was not possible to separate sickness from depressive-like behavior in the present rodent model.
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影响因子：
3.3
作者：
Browne, C. A.;O'Brien, F. E.;Cryan, J. F.
通讯作者：
Cryan, J. F.
DOI：
10.1016/j.bbi.2009.12.008
发表时间：
2010-03
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Buchanan JB;Sparkman NL;Johnson RW
通讯作者：
Johnson RW
影响因子：
15.1
作者：
Erickson, Michelle A.;Banks, William A.
通讯作者：
Banks, William A.
影响因子：
15.1
作者：
Chen, Jing;Buchanan, Jessica B.;Johnson, Rodney W.
通讯作者：
Johnson, Rodney W.
影响因子：
2.3
作者：
Alm, Ann-Sophie;Li, Ka;Wang, Xiangdong
通讯作者：
Wang, Xiangdong