Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis.
Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis.
复制标题
溃疡性结肠炎患者对粪便微生物区系移植(FMT)治疗的反应与真菌跨界动力学有关。
DOI：
10.1016/j.chom.2020.03.006
复制
发表时间：
2020-05-13
影响因子：
30.3
通讯作者：
Iliev ID
中科院分区：
文献类型：
--
作者：
Leonardi I;Paramsothy S;Doron I;Semon A;Kaakoush NO;Clemente JC;Faith JJ;Borody TJ;Mitchell HM;Colombel JF;Kamm MA;Iliev ID
针对肠道菌群的粪便菌群移植（FMT）近年来已成功应用于溃疡性结肠炎的治疗。然而，只有一小部分患者对FMT有反应，因此迫切需要反应性的生物标志物。真菌（mycobiota）是肠道微生物群中具有高度免疫反应性的组成部分。我们分析了来自FMT治疗溃疡性结肠炎（UC）的大型随机对照试验的样本。fmt前念珠菌丰度高与临床反应相关，而fmt后念珠菌丰度降低表明疾病严重程度有所改善。FMT前念珠菌的高含量与FMT后细菌多样性的增加以及与FMT反应性相关的属的存在有关。虽然我们在安慰剂受体中检测到抗念珠菌抗体升高，但这种升高在FMT受体中被消除。我们的数据表明，在肠道疾病期间，FMT可能会减少念珠菌的促炎免疫，并强调了在治疗开始前识别FMT应答者的真菌菌群聚焦方法的实用性。
Fecal microbiota transplantation (FMT) targeting gut microbiota has recently been successfully applied to ulcerative colitis. However, only a subset of patients responds to FMT and there is a pressing need for biomarkers of responsiveness. Fungi (the mycobiota) represent a highly immunologically reactive component of the gut microbiota. We analyzed samples from a large randomized controlled trial of FMT for ulcerative colitis (UC). High Candida abundance pre-FMT was associated with a clinical response, while decreased Candida abundance post-FMT was indicative of ameliorated disease severity. High pre-FMT Candida was associated with increased bacterial diversity post-FMT and the presence of genera linked to FMT responsiveness. Although we detected elevated anti-Candida antibodies in placebo recipients, this increase was abrogated in FMT recipients. Our data suggest that FMT might reduce Candida to contain pro-inflammatory immunity during intestinal disease and highlight the utility of mycobiota–focused approaches to identify FMT responders prior to therapy initiation.
登录
查看更多内容
微生物群转移疗法改变肠道生态系统并改善胃肠道和自闭症症状：一项开放标签研究。
影响因子：
15.5
作者：
Kang DW;Adams JB;Gregory AC;Borody T;Chittick L;Fasano A;Khoruts A;Geis E;Maldonado J;McDonough-Means S;Pollard EL;Roux S;Sadowsky MJ;Lipson KS;Sullivan MB;Caporaso JG;Krajmalnik-Brown R
通讯作者：
Krajmalnik-Brown R
影响因子：
24.5
作者：
Sokol H;Leducq V;Aschard H;Pham HP;Jegou S;Landman C;Cohen D;Liguori G;Bourrier A;Nion-Larmurier I;Cosnes J;Seksik P;Langella P;Skurnik D;Richard ML;Beaugerie L
通讯作者：
Beaugerie L
影响因子：
168.9
作者：
Paramsothy, Sudarshan;Kamm, Michael A.;Borody, Thomas J.
通讯作者：
Borody, Thomas J.
影响因子：
1.7
作者：
Kechin, Andrey;Boyarskikh, Uljana;Filipenko, Maxim
通讯作者：
Filipenko, Maxim
影响因子：
82.9
作者：
通讯作者：
--