Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer.
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer.
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DOI：
10.1038/ncomms1239
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发表时间：
2011
影响因子：
16.6
通讯作者：
Corthay, Alexandre
中科院分区：
文献类型：
--
作者：
Haabeth, Ole Audun Werner;Lorvik, Kristina Berg;Hammarstrom, Clara;Donaldson, Ian M.;Haraldsen, Guttorm;Bogen, Bjarne;Corthay, Alexandre
免疫系统可以促进和抑制癌症。慢性炎症和促炎细胞因子如白细胞介素（IL）-1和IL-6被认为是肿瘤促进。相比之下，保护性抗肿瘤免疫的确切性质仍然不清楚。在这里，我们量化局部分泌的细胞因子在小鼠骨髓瘤和B细胞淋巴瘤的主要免疫反应。引人注目的是，由肿瘤特异性CD 4 + T细胞介导的成功的癌症免疫监视始终与促炎性（IL-1α、IL-1β和IL-6）和辅助性T细胞1（Th 1）相关细胞因子（干扰素-γ（IFN-γ）、IL-2和IL-12）的局部水平升高相关。癌症根除是通过肿瘤特异性Th 1细胞和肿瘤浸润性抗原呈递巨噬细胞之间的合作实现的。Th 1细胞诱导巨噬细胞分泌IL-1β和IL-6。Thl衍生的IFN-γ显示使巨噬细胞对癌细胞具有直接细胞毒性，并诱导巨噬细胞分泌血管生成抑制趋化因子CXCL 9/CXCL 10和CXCL 10/IP-10。因此，当炎症由肿瘤特异性Th 1细胞驱动时，可能会预防而不是促进癌症。 炎症可导致肿瘤的形成，但免疫系统也参与消除癌细胞。在这里，作者表明，由肿瘤特异性CD 4 + T细胞驱动的炎症导致肿瘤消退，并确定了一系列与癌症预防相关的细胞因子。
The immune system can both promote and suppress cancer. Chronic inflammation and proinflammatory cytokines such as interleukin (IL)-1 and IL-6 are considered to be tumour promoting. In contrast, the exact nature of protective antitumour immunity remains obscure. Here, we quantify locally secreted cytokines during primary immune responses against myeloma and B-cell lymphoma in mice. Strikingly, successful cancer immunosurveillance mediated by tumour-specific CD4+ T cells is consistently associated with elevated local levels of both proinflammatory (IL-1α, IL-1β and IL-6) and T helper 1 (Th1)-associated cytokines (interferon-γ (IFN-γ), IL-2 and IL-12). Cancer eradication is achieved by a collaboration between tumour-specific Th1 cells and tumour-infiltrating, antigen-presenting macrophages. Th1 cells induce secretion of IL-1β and IL-6 by macrophages. Th1-derived IFN-γ is shown to render macrophages directly cytotoxic to cancer cells, and to induce macrophages to secrete the angiostatic chemokines CXCL9/MIG and CXCL10/IP-10. Thus, inflammation, when driven by tumour-specific Th1 cells, may prevent rather than promote cancer. Inflammation can result in the formation of tumours, but the immune system is also involved in the elimination of cancer cells. Here, the authors show that inflammation driven by tumour-specific CD4+ T cells results in tumour regression and identify a list of cytokines associated with cancer prevention.
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影响因子：
45.3
作者：
FYFE, G;FISHER, RI;LOUIE, AC
通讯作者：
LOUIE, AC
腋窝淋巴结中免疫细胞的特征可以预测乳腺癌中无疾病的生存。
影响因子：
15.8
作者：
Kohrt, HE;Nouri, N;Nowels, K;Johnson, D;Holmes, S;Lee, PP
通讯作者：
Lee, PP
DOI：
10.1073/pnas.0902745106
发表时间：
2009-04-28
影响因子：
11.1
作者：
Ben-Sasson, Shlomo Z.;Hu-Li, Jane;Paul, William E.
通讯作者：
Paul, William E.
影响因子：
32.4
作者：
DIGHE, AS;RICHARDS, E;SCHREIBER, RD
通讯作者：
SCHREIBER, RD
影响因子：
2.5
作者：
Cherix, Stephane;Speiser, Melanie;Leyvraz, Pierre-Francois
通讯作者：
Leyvraz, Pierre-Francois