Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache.
Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache.
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DOI：
10.1097/j.pain.0000000000001983
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发表时间：
2020-12
期刊：
影响因子：
7.4
通讯作者：
Ramsden CE
中科院分区：
文献类型：
--
作者：
Domenichiello AF;Jensen JR;Zamora D;Horowitz M;Yuan ZX;Faurot K;Mann JD;Mannes AJ;Ramsden CE
慢性创伤后头痛（PTH）是创伤性脑损伤（TBI）最常见和致残的后遗症之一。目前的PTH治疗通常只有部分有效，并有问题的副作用。我们之前在一项针对慢性非创伤性头痛患者的小型随机试验中显示，控制饮食脂肪酸可降低头痛频率、严重程度和止痛药的使用。疼痛减轻与来自n-3和n-6脂肪酸的氧脂素的改变相关，表明氧脂素可能介导临床疼痛减轻。本研究的目的是调查在TBI后急性环境中测量的循环氧脂是否可以作为发展慢性PTH的预后生物标志物。参加创伤性头部损伤神经影像学分类方案的参与者在TBI后3天内提供血清，并在伤后90天进行神经行为症状量表（NSI）和生活满意度调查（SWLS）随访。液相色谱串联质谱法分析了来自n-3二十二碳六烯酸（DHA）、n-6花生四烯酸（AA）和亚油酸（LA）的39种氧脂素。统计分析评估了氧脂素与头痛严重程度的相关性（主要结果，通过NSI头痛问题测量）以及氧脂素与总NSI或SWLS评分之间的相关性。在氧化脂质类中，4-羟基-DHA和19，20-环氧-二十二碳五烯酸酯（DHA衍生物）与头痛严重程度呈负相关，11-羟基-9-环氧-十八碳烯酸酯（LA衍生物）与头痛严重程度呈正相关。这些发现支持DHA衍生的氧化脂质作为慢性PTH发展的预后生物标志物的潜力。
Chronic Post Traumatic Headache (PTH) is among the most common and disabling sequelae of traumatic brain injury (TBI). Current PTH treatments are often only partially effective and have problematic side effects. We previously showed in a small randomized trial of patients with chronic non-traumatic headaches that manipulation of dietary fatty acids decreased headache frequency, severity, and pain medication use. Pain reduction was associated with alterations in oxylipins derived from n-3 and n-6 fatty acids, suggesting that oxylipins could potentially mediate clinical pain reduction. The objective of the present study was to investigate whether circulating oxylipins measured in the acute setting following TBI, could serve as prognostic biomarkers for developing chronic PTH. Participants enrolled in the Traumatic Head Injury Neuroimaging Classification Protocol provided serum within 3 days of TBI and were followed up at 90 days post-injury with a neurobehavioral symptom inventory (NSI) and satisfaction with-life-survey (SWLS). Liquid chromatography tandem mass spectrometry methods profiled 39 oxylipins derived from n-3 docosaheaxaenoic acid (DHA), and n-6 arachidonic acid (AA) and linoleic acid (LA).Statistical analyses assessed the association of oxylipins with headache severity (primary outcome, measured by headache question on NSI) as well as associations between oxylipins and total NSI or SWLS scores. Among oxylipins, 4-hydroxy-DHA and 19,20-epoxy-docosapentaenoate (DHA derivatives) were inversely associated with headache severity, and 11-hydroxy-9-epoxy-octadecenoate (an LA derivative) was positively associated with headache severity. These findings support a potential for DHA-derived oxylipins as prognostic biomarkers for development of chronic PTH.
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影响因子：
8.8
作者：
Orr SK;Butler KL;Hayden D;Tompkins RG;Serhan CN;Irimia D
通讯作者：
Irimia D
影响因子：
4.2
作者：
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通讯作者：
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影响因子：
2
作者：
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通讯作者：
Defrin, Ruth
影响因子：
1.6
作者：
Kaufmann, I.;Hauer, D.;Schelling, G.
通讯作者：
Schelling, G.
DOI：
10.1016/s0003-9993(96)90275-0
发表时间：
1996-09-01
影响因子：
4.3
作者：
Lahz, S;Bryant, RA
通讯作者：
Bryant, RA