REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.
复制标题
REGN-COV2抗体预防和治疗恒河猕猴和仓鼠中的SARS-COV-2感染。
DOI：
10.1126/science.abe2402
复制
发表时间：
2020-11-27
期刊：
影响因子：
--
通讯作者：
Kyratsous CA
中科院分区：
文献类型：
--
作者：
Baum A;Ajithdoss D;Copin R;Zhou A;Lanza K;Negron N;Ni M;Wei Y;Mohammadi K;Musser B;Atwal GS;Oyejide A;Goez-Gazi Y;Dutton J;Clemmons E;Staples HM;Bartley C;Klaffke B;Alfson K;Gazi M;Gonzalez O;Dick E Jr;Carrion R Jr;Pessaint L;Porto M;Cook A;Brown R;Ali V;Greenhouse J;Taylor T;Andersen H;Lewis MG;Stahl N;Murphy AJ;Yancopoulos GD;Kyratsous CA
自2019年冠状病毒病（COVID-19）大流行开始以来，已投入相当大的努力来产生和表征可用作治疗剂的中和抗体。在人源化小鼠和康复期人类中的研究导致开发了两种有效抗体的混合物，它们同时结合严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）刺突蛋白并阻止病毒进入宿主细胞。Baum等人评价了这种混合物REGN-COV 2在恒河猴（可能模拟轻度疾病）和金黄色仓鼠（表现出更严重的症状）中的疗效。抗体混合物在两种模型中以免疫或治疗方式给药时均提供了益处，目前正在进行临床试验。《科学》，本期第1110页，在SARS-CoV-2感染的恒河猴和金黄仓鼠模型中评价了REGN-COV 2抗体混合物的体内疗效。全球正在紧急寻求预防和治疗2019冠状病毒病（COVID-19）的有效疗法。我们先前描述了REGN-COV 2，这是两种有效中和抗体（REGN 10987和REGN 10933）的混合物，靶向严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白上的非重叠表位。在这份报告中，我们评估了这种抗体鸡尾酒在恒河猴（可能是轻度疾病的模型）和金黄色仓鼠（可能是更严重疾病的模型）中的体内疗效。我们证明，当在恒河猴中进行预防性或治疗性给药时，REGN-COV-2可大大降低下呼吸道和上呼吸道中的病毒载量，并减少病毒诱导的病理后遗症。类似地，在仓鼠中给药限制了体重减轻并降低了肺滴度和肺中肺炎的证据。我们的研究结果提供了这种抗体鸡尾酒的治疗潜力的证据。
Since the start of the coronavirus disease 2019 (COVID-19) pandemic, considerable effort has gone into generating and characterizing neutralizing antibodies that could be used as therapeutics. Studies in humanized mice and convalescent humans led to the development of a cocktail of two potent antibodies that simultaneously bind to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prevent the virus from entering host cells. Baum et al. evaluated the efficacy of this cocktail, REGN-COV2, in rhesus macaques, which may model mild disease, and in golden hamsters, which present more severe symptoms. The antibody cocktail provided benefits in both models when administered either prophylactically or therapeutically and is currently in clinical trials. Science, this issue p. 1110 In vivo efficacy of the REGN-COV2 antibody cocktail is evaluated in the rhesus macaque and golden hamster models of SARS-CoV-2 infection. An urgent global quest for effective therapies to prevent and treat coronavirus disease 2019 (COVID-19) is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987 and REGN10933) that targets nonoverlapping epitopes on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques, which may model mild disease, and golden hamsters, which may model more severe disease. We demonstrate that REGN-COV-2 can greatly reduce virus load in the lower and upper airways and decrease virus-induced pathological sequelae when administered prophylactically or therapeutically in rhesus macaques. Similarly, administration in hamsters limits weight loss and decreases lung titers and evidence of pneumonia in the lungs. Our results provide evidence of the therapeutic potential of this antibody cocktail.
登录
查看更多内容
Chadox1 NCOV-19疫苗可防止恒河猕猴中的SARS-COV-2肺炎。
影响因子：
64.8
作者：
van Doremalen N;Lambe T;Spencer A;Belij-Rammerstorfer S;Purushotham JN;Port JR;Avanzato VA;Bushmaker T;Flaxman A;Ulaszewska M;Feldmann F;Allen ER;Sharpe H;Schulz J;Holbrook M;Okumura A;Meade-White K;Pérez-Pérez L;Edwards NJ;Wright D;Bissett C;Gilbride C;Williamson BN;Rosenke R;Long D;Ishwarbhai A;Kailath R;Rose L;Morris S;Powers C;Lovaglio J;Hanley PW;Scott D;Saturday G;de Wit E;Gilbert SC;Munster VJ
通讯作者：
Munster VJ
影响因子：
120.7
作者：
Li, Ling;Zhang, Wei;Liu, Zhong
通讯作者：
Liu, Zhong
影响因子：
82.9
作者：
He, Xi;Lau, Eric H. Y.;Leung, Gabriel M.
通讯作者：
Leung, Gabriel M.
影响因子：
56.9
作者：
Chandrashekar, Abishek;Liu, Jinyan;Barouch, Dan H.
通讯作者：
Barouch, Dan H.
影响因子：
64.5
作者：
Korber, Bette;Fischer, Will M.;Montefiori, David C.
通讯作者：
Montefiori, David C.