Ginger Extract Decreases Susceptibility to Dextran Sulfate Sodium-Induced Colitis in Mice Following Early Antibiotic Exposure.
Ginger Extract Decreases Susceptibility to Dextran Sulfate Sodium-Induced Colitis in Mice Following Early Antibiotic Exposure.
复制标题
生姜提取物可降低小鼠早期接触抗生素后对右旋糖酐硫酸钠诱导的结肠炎的易感性
DOI：
10.3389/fmed.2021.755969
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发表时间：
2021
影响因子：
3.9
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Zhou X;Liu X;He Q;Wang M;Lu H;You Y;Chen L;Cheng J;Li F;Fu X;Kwan HY;Zhou L;Zhao X
背景：生命早期的肠道微生物定植在免疫发育和晚年的粘膜稳态中起着至关重要的作用。早期抗生素暴露会增加炎症性肠病（IBD）的风险。生姜的作用就像一种益生元，已被用于治疗结肠炎的中药中。我们研究了生姜对葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎的保护作用。方法：采用阿奇霉素（AZT）暴露2周的断乳小鼠模型，模拟人类儿童期抗生素暴露。在抗生素暴露后，将含有生姜提取物的饮食给予小鼠4周。根据体重减轻、疾病活动指数（DAI）评分、结肠长度、结肠炎生物标志物和肠屏障功能评价DSS诱导的结肠炎的易感性。根据16S rRNA水平分析肠道微生物群。结果如下：生姜提取物可预防早期接触抗生素的小鼠体重减轻、结肠缩短、炎症和肠屏障功能障碍。生姜增加了细菌的多样性，改变了属于消化球菌科和螺杆菌属的细菌的丰度，以调节受早期抗生素暴露不利影响的微生物群结构和组成。结论：生姜具有潜在的保护作用，可以降低早期暴露于抗生素的小鼠对结肠炎的易感性。图形摘要生姜提取物降低敏感性葡聚糖硫酸钠诱导的结肠炎小鼠早期抗生素暴露。
Background: Intestinal microbial colonization in early life plays a crucial role in immune development and mucosal homeostasis in later years. Antibiotic exposure in early life increases the risk of inflammatory bowel disease (IBD). Ginger acts like a prebiotic and has been used in traditional Chinese medicine for colitis. We investigated the protective effect of ginger against dextran sulfate sodium (DSS)-induced colitis in mice exposed to antibiotic in their early years. Methods: A weaned mouse model exposed to azithromycin (AZT) for 2 weeks was used to mimic antibiotic exposure in childhood among humans. A diet containing ginger extract was administered to mice for 4 weeks after antibiotic exposure. The susceptibility to DSS-induced colitis was evaluated in terms of weight loss, disease activity index (DAI) score, colon length, colitis biomarkers, and intestinal barrier function. The gut microbiota was analyzed in terms of 16S rRNA levels. Results: Ginger extract prevented weight loss, colon shortening, inflammation, and intestinal barrier dysfunction in mice exposed to antibiotics in early life. Ginger increased the bacterial diversity and changed the abundance of bacterial belonging to family Peptococcaceae and Helicobacter species to modulate microbiota structure and composition adversely affected by early antibiotic exposure. Conclusion: Ginger has a protective effect in potentially decreasing the susceptibility to colitis in mice exposed to antibiotics early in life. Graphical Abstract Ginger extract decreases susceptibility to dextran sulfate sodium-induced colitis in mice following early antibiotic exposure.
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影响因子：
24.5
作者：
Luther J;Owyang SY;Takeuchi T;Cole TS;Zhang M;Liu M;Erb-Downward J;Rubenstein JH;Chen CC;Pierzchala AV;Paul JA;Kao JY
通讯作者：
Kao JY
影响因子：
8
作者：
通讯作者：
--
影响因子：
8
作者：
Bartels, Lars E.;Jepsen, Peter;Dahlerup, Jens F.
通讯作者：
Dahlerup, Jens F.
影响因子：
82.9
作者：
Barcena, Clea;Valdes-Mas, Rafael;Lopez-Otin, Carlos
通讯作者：
Lopez-Otin, Carlos
影响因子：
82.9
作者：
Depommier, Clara;Everard, Amandine;Cani, Patrice D.
通讯作者：
Cani, Patrice D.