Expression of CIDE proteins in clear cell renal cell carcinoma and their prognostic significance.
Expression of CIDE proteins in clear cell renal cell carcinoma and their prognostic significance.
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CIDE蛋白在透明细胞肾细胞癌中的表达及其预后意义
DOI：
10.1007/s11010-013-1605-y
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发表时间：
2013-06
影响因子：
4.3
通讯作者：
Ye, Jing
中科院分区：
文献类型：
--
作者：
Yu, Ming;Wang, Hui;Zhao, Jun;Yuan, Yuan;Wang, Chao;Li, Jing;Zhang, Lijun;Zhang, Liying;Li, Qing;Ye, Jing
肾透明细胞癌（Clear cell renal cell carcinoma，ccRCC）是肾细胞癌的主要和侵袭性亚型。已知其组织学表现来自于丰富的脂质和糖原的积累。细胞死亡诱导DFF45样效应子（锡德）家族被表征为参与脂质储存液滴代谢的脂滴蛋白。本研究的目的是评估锡德蛋白在ccRCC细胞中的表达并研究其预后意义。我们检查了连续接受肾切除术的散发性ccRCC患者，以测量他们的锡德蛋白的mRNA和蛋白表达。我们发现，与正常肾组织相比，Cidec和ADRP在ccRCC中的表达显著上调。Cideb被下调。我们还发现Cideb在低级别ccRCC中的表达高于高级别肿瘤。为了进一步阐明Cideb表达与患者预后之间的关系，我们对57例ccRCC患者进行了120个月的随访。ccRCC Cideb表达降低与较高的Fuhrman核分级相关。Cideb高表达患者的总生存率高于低表达患者（p< 0.05）。Cideb表达是生存的独立预测因子（p= 0.001）。虽然Cideb在ccRCC中的生物学功能尚不清楚，但Cideb的表达水平可能是ccRCC预后的新预测因子。
Clear cell renal cell carcinoma (ccRCC) is the major and aggressive subtype of renal cell carcinoma. It is known to derive its histologic appearance from accumulation of abundant lipids and glycogens. The cell death-inducing DFF45-like effector (CIDE) family has been characterized as the lipid droplet proteins involved in the metabolism of lipid storage droplets. The purpose of this study was to evaluate the expression of CIDE proteins in ccRCC cells and to investigate their prognostic significance. We examined consecutive patients with sporadic ccRCC, who underwent nephrectomy, to measure their mRNA and protein expression of CIDE proteins. We found that Cidec and ADRP expression were significantly up-regulated in ccRCC, compared with normal kidney tissues. Cideb was down-regulated. We also found that Cideb was expressed more in low-grade ccRCC than in high-grade tumors. To further clarify the relationship between Cideb expression and patient prognosis, we evaluated 57 ccRCC patients followed up for 120 months. Reduced ccRCC Cideb expression was associated with a higher Fuhrman nuclear grade. Patients with high Cideb expression had better overall survival rate than those with low expression (p< 0.05). Cideb expression was an independent predictor of survival (p= 0.001). Although the biologic function of Cideb in ccRCC remains unknown, the expression level of Cideb might be a novel predictor of prognosis in ccRCC.
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影响因子：
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作者：
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