Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database.
Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database.
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DOI：
10.1371/journal.pone.0059341
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mimori T
中科院分区：
文献类型：
--
作者：
Terao C;Hashimoto M;Yamamoto K;Murakami K;Ohmura K;Nakashima R;Yamakawa N;Yoshifuji H;Yukawa N;Kawabata D;Usui T;Yoshitomi H;Furu M;Yamada R;Matsuda F;Ito H;Fujii T;Mimori T
类风湿性关节炎（RA）是一种破坏关节的自身免疫性疾病。三个综合指数评价相同的28个关节通常用于评估RA活动。然而，关节受累之间的关系和频率仍然没有完全了解。在这里，我们从KURAMA（京都大学风湿性关节炎管理联盟）数据库中存储的电子临床图表模板中获得并分析了2005年至2011年1，314例RA患者28个关节的17，311项评估。对28个关节中的每一个关节的肿胀和压痛的受影响率进行评估，并在两组不同的RA患者之间进行比较。采用主成分分析法，利用Kappa系数和特征向量分析关节症状与关节肿胀和压痛的相关性。结果，我们发现两组的关节受累率在关节压痛和肿胀方面存在很大差异。右腕关节是28个关节中最受影响的关节。除肩关节外，肌腱和肌腱在同一关节中具有良好的相关性。RA患者倾向于表现出右优势关节受累和关节破坏。我们还发现RA滑膜炎在相关性分析中可以分为三类关节：大关节与腕关节、PIP关节和MCP关节。根据滑膜炎的分布进行聚类分析，发现RA患者可分为6个亚组。我们证实了RA的对称性关节受累。我们的研究结果表明，RA滑膜炎可以分为亚组，几种不同的机制可能是RA滑膜炎的病理生理基础。
Rheumatoid arthritis (RA) is a joint-destructive autoimmune disease. Three composite indices evaluating the same 28 joints are commonly used for the evaluation of RA activity. However, the relationship between, and the frequency of, the joint involvements are still not fully understood. Here, we obtained and analyzed 17,311 assessments for 28 joints in 1,314 patients with RA from 2005 to 2011 from electronic clinical chart templates stored in the KURAMA (Kyoto University Rheumatoid Arthritis Management Alliance) database. Affected rates for swelling and tenderness were assessed for each of the 28 joints and compared between two different sets of RA patients. Correlations of joint symptoms were analyzed for swellings and tenderness using kappa coefficient and eigen vectors by principal component analysis. As a result, we found that joint affected rates greatly varied from joint to joint both for tenderness and swelling for the two sets. Right wrist joint is the most affected joint of the 28 joints. Tenderness and swellings are well correlated in the same joints except for the shoulder joints. Patients with RA tended to demonstrate right-dominant joint involvement and joint destruction. We also found that RA synovitis could be classified into three categories of joints in the correlation analyses: large joints with wrist joints, PIP joints, and MCP joints. Clustering analysis based on distribution of synovitis revealed that patients with RA could be classified into six subgroups. We confirmed the symmetric joint involvement in RA. Our results suggested that RA synovitis can be classified into subgroups and that several different mechanisms may underlie the pathophysiology in RA synovitis.
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影响因子：
--
作者：
Scheel, Alexander K.;Hermann, Kay-Geert A.;Backhaus, Marina
通讯作者：
Backhaus, Marina
DOI：
10.1002/art.24646
发表时间：
2009-09-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Backhaus, M.;Ohrndorf, S.;Schmidt, W. A.
通讯作者：
Schmidt, W. A.
影响因子：
27.4
作者：
Aletaha, Daniel;Neogi, Tuhina;Hawker, Gillian
通讯作者：
Hawker, Gillian
影响因子：
--
作者：
Aletaha, Daniel;Neogi, Tuhina;Hawker, Gillian
通讯作者：
Hawker, Gillian
影响因子：
--
作者：
ARNETT, FC;EDWORTHY, SM;HUNDER, GG
通讯作者：
HUNDER, GG