Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization.
Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization.
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DOI：
10.3389/fonc.2022.1022716
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发表时间：
2022
影响因子：
4.7
通讯作者：
Deleyrolle, Loic P.
中科院分区：
文献类型：
--
作者：
Silver, Aryeh;Feier, Diana;Ghosh, Tanya;Rahman, Maryam;Huang, Jianping;Sarkisian, Matthew R.;Deleyrolle, Loic P.
关键词：
胶质母细胞瘤（GBM）是一种极具侵袭性且无法治愈的原发性脑肿瘤，10年生存率仅为0.71%。癌症干细胞（CSCs）被认为通过逃避标准的护理治疗（包括手术切除、放疗和化疗）而导致GBM不可避免的复发，导致这种严峻的预后。有效靶向CSCs可能有助于深入了解GBM治疗耐药性和开发新的治疗范例。目前正在进行的主要工作是表征CSCs，了解它们与肿瘤微环境的相互作用，并确定消除它们的方法。本文讨论了胶质瘤干细胞谱系的多样性，以及这种胶质瘤干细胞（GSC）嵌合如何驱动由复杂和空间上不同的局部微环境构成的全局肿瘤内异质性。我们回顾了肿瘤的不同CSC群体如何协调和与环境，特别是免疫景观相互作用。我们还讨论了如何通过代谢和免疫学的镜头来绘制这个复杂的GBM生态系统，以发现脆弱性和新的方法来破坏系统的平衡，以实现改善的疾病结果。
Glioblastoma (GBM) is an extremely aggressive and incurable primary brain tumor with a 10-year survival of just 0.71%. Cancer stem cells (CSCs) are thought to seed GBM’s inevitable recurrence by evading standard of care treatment, which combines surgical resection, radiotherapy, and chemotherapy, contributing to this grim prognosis. Effective targeting of CSCs could result in insights into GBM treatment resistance and development of novel treatment paradigms. There is a major ongoing effort to characterize CSCs, understand their interactions with the tumor microenvironment, and identify ways to eliminate them. This review discusses the diversity of CSC lineages present in GBM and how this glioma stem cell (GSC) mosaicism drives global intratumoral heterogeneity constituted by complex and spatially distinct local microenvironments. We review how a tumor’s diverse CSC populations orchestrate and interact with the environment, especially the immune landscape. We also discuss how to map this intricate GBM ecosystem through the lens of metabolism and immunology to find vulnerabilities and new ways to disrupt the equilibrium of the system to achieve improved disease outcome.
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DOI：
10.1038/s41568-021-00397-3
发表时间：
2021-12
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Andersen BM;Faust Akl C;Wheeler MA;Chiocca EA;Reardon DA;Quintana FJ
通讯作者：
Quintana FJ
影响因子：
64.5
作者：
Bonaguidi MA;Wheeler MA;Shapiro JS;Stadel RP;Sun GJ;Ming GL;Song H
通讯作者：
Song H
影响因子：
32.4
作者：
Agudo J;Park ES;Rose SA;Alibo E;Sweeney R;Dhainaut M;Kobayashi KS;Sachidanandam R;Baccarini A;Merad M;Brown BD
通讯作者：
Brown BD
影响因子：
--
作者：
Bier A;Giladi N;Kronfeld N;Lee HK;Cazacu S;Finniss S;Xiang C;Poisson L;deCarvalho AC;Slavin S;Jacoby E;Yalon M;Toren A;Mikkelsen T;Brodie C
通讯作者：
Brodie C
影响因子：
29
作者：
Angelin A;Gil-de-Gómez L;Dahiya S;Jiao J;Guo L;Levine MH;Wang Z;Quinn WJ 3rd;Kopinski PK;Wang L;Akimova T;Liu Y;Bhatti TR;Han R;Laskin BL;Baur JA;Blair IA;Wallace DC;Hancock WW;Beier UH
通讯作者：
Beier UH