Glial and myeloid heterogeneity in the brain tumour microenvironment.
Glial and myeloid heterogeneity in the brain tumour microenvironment.
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DOI：
10.1038/s41568-021-00397-3
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Quintana FJ
中科院分区：
文献类型：
--
作者：
Andersen BM;Faust Akl C;Wheeler MA;Chiocca EA;Reardon DA;Quintana FJ
脑癌的前景黯淡，在过去的十年里，治疗的进步只帮助了一小部分患者。脑肿瘤微环境(TME)具有高度的免疫抑制作用，与其他恶性肿瘤不同，其原因在于构成它的神经胶质细胞、神经细胞和免疫细胞群。直到最近，由于缺乏在单细胞水平上分解这一复杂系统的方法，对大脑TME的研究一直受到限制。然而，新的技术方法已经开始揭示TME中不同的神经胶质细胞和髓系细胞群的免疫抑制和促肿瘤特性，从而确定新的治疗机会。在这里，我们讨论了小胶质细胞、单核细胞来源的巨噬细胞和星形胶质细胞在脑转移瘤和胶质瘤中的免疫调节功能，强调了它们与疾病相关的异质性，并借鉴了通过研究这些恶性肿瘤和其他神经疾病所获得的见解。最后，我们考虑了对大脑TME进行治疗调节的潜在方法。
Brain cancers carry bleak prognoses, with therapeutic advances helping only a minority of patients over the past decade. The brain tumour microenvironment (TME) is highly immunosuppressive and differs from that of other malignancies as a result of the glial, neural and immune cell populations that constitute it. Until recently, the study of the brain TME was limited by the lack of methods to de-convolute this complex system at the single-cell level. However, novel technical approaches have begun to reveal the immunosuppressive and tumour-promoting properties of distinct glial and myeloid cell populations in the TME, identifying new therapeutic opportunities. Here, we discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma, highlighting their disease-associated heterogeneity and drawing from the insights gained by studying these malignancies and other neurological disorders. Lastly, we consider potential approaches for the therapeutic modulation of the brain TME.
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影响因子：
10.5
作者：
Amankulor NM;Kim Y;Arora S;Kargl J;Szulzewsky F;Hanke M;Margineantu DH;Rao A;Bolouri H;Delrow J;Hockenbery D;Houghton AM;Holland EC
通讯作者：
Holland EC
影响因子：
64.8
作者：
Capper D;Jones DTW;Sill M;Hovestadt V;Schrimpf D;Sturm D;Koelsche C;Sahm F;Chavez L;Reuss DE;Kratz A;Wefers AK;Huang K;Pajtler KW;Schweizer L;Stichel D;Olar A;Engel NW;Lindenberg K;Harter PN;Braczynski AK;Plate KH;Dohmen H;Garvalov BK;Coras R;Hölsken A;Hewer E;Bewerunge-Hudler M;Schick M;Fischer R;Beschorner R;Schittenhelm J;Staszewski O;Wani K;Varlet P;Pages M;Temming P;Lohmann D;Selt F;Witt H;Milde T;Witt O;Aronica E;Giangaspero F;Rushing E;Scheurlen W;Geisenberger C;Rodriguez FJ;Becker A;Preusser M;Haberler C;Bjerkvig R;Cryan J;Farrell M;Deckert M;Hench J;Frank S;Serrano J;Kannan K;Tsirigos A;Brück W;Hofer S;Brehmer S;Seiz-Rosenhagen M;Hänggi D;Hans V;Rozsnoki S;Hansford JR;Kohlhof P;Kristensen BW;Lechner M;Lopes B;Mawrin C;Ketter R;Kulozik A;Khatib Z;Heppner F;Koch A;Jouvet A;Keohane C;Mühleisen H;Mueller W;Pohl U;Prinz M;Benner A;Zapatka M;Gottardo NG;Driever PH;Kramm CM;Müller HL;Rutkowski S;von Hoff K;Frühwald MC;Gnekow A;Fleischhack G;Tippelt S;Calaminus G;Monoranu CM;Perry A;Jones C;Jacques TS;Radlwimmer B;Gessi M;Pietsch T;Schramm J;Schackert G;Westphal M;Reifenberger G;Wesseling P;Weller M;Collins VP;Blümcke I;Bendszus M;Debus J;Huang A;Jabado N;Northcott PA;Paulus W;Gajjar A;Robinson GW;Taylor MD;Jaunmuktane Z;Ryzhova M;Platten M;Unterberg A;Wick W;Karajannis MA;Mittelbronn M;Acker T;Hartmann C;Aldape K;Schüller U;Buslei R;Lichter P;Kool M;Herold-Mende C;Ellison DW;Hasselblatt M;Snuderl M;Brandner S;Korshunov A;von Deimling A;Pfister SM
通讯作者：
Pfister SM
DOI：
10.1158/1078-0432.ccr-20-1303
发表时间：
2020-10-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Ahmed FS;Gaule P;McGuire J;Patel K;Blenman K;Pusztai L;Rimm DL
通讯作者：
Rimm DL
影响因子：
16.6
作者：
Batiuk, Mykhailo Y.;Martirosyan, Araks;Holt, Matthew G.
通讯作者：
Holt, Matthew G.
影响因子：
9.8
作者：
Benbenishty, Amit;Gadrich, Meital;Blinder, Pablo
通讯作者：
Blinder, Pablo