Reexperiencing and anxious arousal symptoms in relation to volumes of thalamus nuclei in posttraumatic stress spectrum adults.
Reexperiencing and anxious arousal symptoms in relation to volumes of thalamus nuclei in posttraumatic stress spectrum adults.
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DOI：
10.1002/brb3.2639
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发表时间：
2022-07
影响因子：
3.1
通讯作者：
Rosso, Isabelle M.
中科院分区：
文献类型：
--
作者：
Casteen, Emily J.;Nielsen, Sienna R.;Olson, Elizabeth A.;Frederiks, Kevin;Rosso, Isabelle M.
Trauma reexperiencing is dominated by recollection of sensory‐perceptual elements of the trauma, pointing to involvement of the sensory thalamus. This study examined posttraumatic stress symptoms in relation to volumes of thalamic nuclei that were grouped based on their predominant functions. We hypothesized that reexperiencing, controlling for other symptom dimensions, would correlate with volumes of thalamic nuclei involved in primary and higher‐order sensory processing. Seventy‐two trauma‐exposed adults were interviewed with the Clinician Administered PTSD Scale for DSM‐IV and underwent 3T magnetic resonance imaging. Scores were derived for reexperiencing, anxious arousal, dysphoric arousal, emotional numbing, and avoidance symptoms. These were entered as simultaneous predictors in five separate regression analyses, with age, sex, and total thalamus volume as covariates, predicting volumesf of five thalamus nuclear groupings corrected for intracranial volume: Specific sensory, associative‐sensory, associative‐cognitive, intralaminar, and motor groupings. Reexperiencing symptoms were significantly positively correlated with volumes of the motor thalamic grouping, which included the ventral anterior, ventral lateral, and ventromedial nuclei. Anxious arousal was significantly negatively correlated with volumes of all five thalamic groupings. Reexperiencing symptoms were correlated with volumes of the motor thalamus, while anxious arousal symptoms were related to all thalamic subregion volumes. Thalamic nuclei involved in motor functions, including oculomotor control and motor planning, may be implicated in posttraumatic reexperiencing symptoms. Posttraumatic stress disorder involves reexperiencing of a traumatic experience, including its sensory‐perceptual elements. This study examined reexperiencing and other posttraumatic stress symptoms in relation to volumes of thalamic nuclei that were grouped based on their role in particular functions (sensory, cognitive, motor, arousal). We found that reexperiencing symptoms were associated with volumes of the motor thalamus, while anxious arousal symptoms are related to the size of all thalamic subregion volumes. These results suggest that thalamic nuclei involved in oculomotor control and motor planning may be implicated in posttraumatic reexperiencing symptoms.
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