Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking.
Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking.
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DOI：
10.3390/toxics11100855
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发表时间：
2023-10-13
期刊：
影响因子：
4.6
通讯作者：
Folger AT
中科院分区：
文献类型：
--
作者：
Nidey N;Bowers K;Ding L;Ji H;Ammerman RT;Yolton K;Mahabee-Gittens EM;Folger AT
(1)引言：表观遗传学变化被认为是子宫内暴露于母亲吸烟和健康结果之间的生物学联系。因此，我们研究了母亲在子宫内吸烟是否与精氨酸加压素受体1A AVPR 1a基因中胞嘧啶磷酸鸟嘌呤二核苷酸（CpG位点）的婴儿DNA甲基化（DNAm）相关。AVPR 1a基因编码一种与精氨酸加压素激素相互作用的受体，可能影响生理应激调节、血压和儿童发育。(2)方法：52名婴儿纳入本队列研究。使用多变量线性模型来检查子宫内暴露于母亲吸烟对位于AVPR 1a的CpG位点平均DNA m的影响。(3)结果如下：调整物质使用模型后，宫内暴露于母亲吸烟的婴儿在一个月大时AVPR 1a CpG位点的DNAm减少了-0.02（95%CI-0.03，-0.01）。总之，宫内暴露于烟草烟雾可导致婴儿AVPR 1a的DNAm差异模式。结论：未来的研究需要确定基因表达如何响应早期环境暴露有助于健康结果。
(1) Introduction: Epigenetic changes have been proposed as a biologic link between in-utero exposure to maternal smoking and health outcomes. Therefore, we examined if in-utero exposure to maternal smoking was associated with infant DNA methylation (DNAm) of cytosine-phosphate-guanine dinucleotides (CpG sites) in the arginine vasopressin receptor 1A AVPR1a gene. The AVPR1a gene encodes a receptor that interacts with the arginine vasopressin hormone and may influence physiological stress regulation, blood pressure, and child development. (2) Methods: Fifty-two infants were included in this cohort study. Multivariable linear models were used to examine the effect of in-utero exposure to maternal smoking on the mean DNAm of CpG sites located at AVPR1a. (3) Results: After adjusting the model for substance use, infants with in-utero exposure to maternal smoking had a reduction in DNAm at AVPR1a CpG sites by −0.02 (95% CI −0.03, −0.01) at one month of age. In conclusion, in-utero exposure to tobacco smoke can lead to differential patterns of DNAm of AVPR1a among infants. Conclusions: Future studies are needed to identify how gene expression in response to early environmental exposures contributes to health outcomes.
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影响因子：
3.7
作者：
Abraham M;Alramadhan S;Iniguez C;Duijts L;Jaddoe VW;Den Dekker HT;Crozier S;Godfrey KM;Hindmarsh P;Vik T;Jacobsen GW;Hanke W;Sobala W;Devereux G;Turner S
通讯作者：
Turner S
影响因子：
4.5
作者：
Li G;Wang H;Wang K;Wang W;Dong F;Qian Y;Gong H;Hui C;Xu G;Li Y;Pan L;Zhang B;Shan G
通讯作者：
Shan G
影响因子：
7.4
作者：
Banderali G;Martelli A;Landi M;Moretti F;Betti F;Radaelli G;Lassandro C;Verduci E
通讯作者：
Verduci E
影响因子：
5.1
作者：
Hamoen, Marleen;Welten, Marieke;de Kroon, Marlou L. A.
通讯作者：
de Kroon, Marlou L. A.
影响因子：
9.8
作者：
Joubert, Bonnie R.;Felix, Janine F.;London, Stephanie J.
通讯作者：
London, Stephanie J.