The penetration and movement of nanoparticles on membrane

The penetration and movement of nanoparticles on membrane
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纳米颗粒在膜上的渗透和运动

DOI:
10.1117/12.2544321
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发表时间:
2020
期刊:
and Molecular Probes for Biomedical Applications XII
影响因子:
--
通讯作者:
Ren, Jun
Ren, Jun
中科院分区:
--
文献类型:
--
作者:
Xin, Lianxin;Wang, Zixuan;Zhao, Jian;Tylor, Zachary B.;Boukari, Hacene;Zerrad, Essaid;Ren, Jun

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在这项研究中,我们使用GROMACS,一个多功能的软件包进行分子动力学模拟不同的纳米粒子和二棕榈酰磷脂酰胆碱(DPPC)之间的相互作用,以了解管理纳米粒子和脂质膜之间的相互作用的物理机制。我们的模拟显示了脂质双层对纳米颗粒的响应,包括在纳米颗粒表面形成吸附层,跨膜异位运动和膜对纳米颗粒的不明显的内吞作用。纳米粒子的大小,结构形状和电荷状态的相互作用和传输过程的影响将进行检查和总结。
In this study, we used GROMACS, a versatile package for performing molecular dynamics to simulate the interactions between different nanoparticles and Dipalmitoyl PhosPhatidyl Choline (DPPC) to understand the physical mechanisms that govern the interactions between nanoparticles and lipid membrane. Our simulations show the responses of the lipid bilayer to the nanoparticles, including the formation of an adsorbent layer on the nanoparticle surface, transmembrane ectopic movements and inconspicuous endocytosis of the nanoparticle by the membrane. Effects of the size of the nanoparticles, structural shape and charge state on the interaction and transport processes will be examined and summarized.
DOI: 10.1039/c5nr02255j
发表时间: 2015-09-14
期刊: Nanoscale
影响因子: 6.7
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