Biophysical interactions with model lipid membranes: applications in drug discovery and drug delivery.
Biophysical interactions with model lipid membranes: applications in drug discovery and drug delivery.
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DOI：
10.1021/mp9000662
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发表时间：
2009-09
影响因子：
4.9
通讯作者：
Labhasetwar V
中科院分区：
文献类型：
--
作者：
Peetla C;Stine A;Labhasetwar V
药物或药物递送系统穿过细胞膜的运输是一个复杂的生物过程，由于其动态性质而通常难以理解。在这方面，模型脂质膜，模拟细胞膜脂质的许多方面，已经非常有用，帮助研究人员辨别脂质在细胞相互作用中的作用。人们可以使用药物-脂质相互作用来预测药物的药代动力学性质，例如它们的转运、生物分布、积累以及因此的功效。基于药物分子的结构和亲水性/疏水性，这些相互作用也可用于研究转运机制。近年来，模型脂质膜也被探索，以了解其与肽，聚合物和纳米载体的相互作用机制。这些相互作用研究可用于设计和开发有效的药物递送系统。在某些疾病条件下，细胞和组织的脂质组成的变化可能会改变生物物理相互作用，这可以被探索以开发靶向特异性药物和药物递送系统。在这篇综述中，我们讨论了不同的模型膜，药物-脂质相互作用及其意义，模型膜与纳米载体的相互作用的研究，以及如何与脂质模型膜的生物物理相互作用的研究可以在药物发现和药物输送中发挥重要作用。
The transport of drugs or drug delivery systems across the cell membrane is a complex biological process, often difficult to understand because of its dynamic nature. In this regard, model lipid membranes, which mimic many aspects of cell-membrane lipids, have been very useful in helping investigators to discern the roles of lipids in cellular interactions. One can use drug-lipid interactions to predict pharmacokinetic properties of drugs, such as their transport, biodistribution, accumulation, and hence efficacy. These interactions can also be used to study the mechanisms of transport, based on the structure and hydrophilicity/hydrophobicity of drug molecules. In recent years, model lipid membranes have also been explored to understand their mechanisms of interactions with peptides, polymers, and nanocarriers. These interaction studies can be used to design and develop efficient drug delivery systems. Changes in the lipid composition of cells and tissue in certain disease conditions may alter biophysical interactions, which could be explored to develop target-specific drugs and drug delivery systems. In this review, we discuss different model membranes, drug-lipid interactions and their significance, studies of model membrane interactions with nanocarriers, and how biophysical interaction studies with lipid model membranes could play an important role in drug discovery and drug delivery.
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影响因子：
15.6
作者：
Brezesinski, G;Möhwald, H
通讯作者：
Möhwald, H
影响因子：
2.9
作者：
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影响因子：
5.3
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影响因子：
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影响因子：
3.4
作者：
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通讯作者：
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