Modular organization of murine locomotor pattern in the presence and absence of sensory feedback from muscle spindles
Modular organization of murine locomotor pattern in the presence and absence of sensory feedback from muscle spindles
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在存在或不存在肌梭感觉反馈的情况下小鼠运动模式的模块化组织
DOI：
10.1113/jp277515
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Arampatzis A
中科院分区：
文献类型：
--
作者：
Santuz A;Akay T;Mayer WP;Wells TL;Schroll A;Arampatzis A
关键点在陆地和水中的运动需要协调大量的肌肉激活和关节运动。关于自身身体部位与周围环境和身体本身的位置的持续反馈中枢神经系统可能遵循一种模块化的组织方式，通过控制协调的肌肉群来控制肌肉。（肌肉协同作用）而不是单独使用。我们将这一概念用于缺乏肌梭的转基因小鼠，肌梭是两种主要的本体感受器之一。我们提供的证据表明，中枢神经系统需要本体感受反馈来精确调节运动的模块化组织。脊椎动物必须根据大量的变量来构建它们的运动模式。大量的肌肉和关节，加上对感觉反馈信息（例如本体感受）的持续需求，使得控制运动的任务成为自由度过多的问题。人们普遍认为，中枢神经系统可以通过产生肌肉群共同的激活模式而不是特定于单个肌肉来简化运动的产生和控制。这些被称为肌肉协同作用的激活模式描述了运动的模块化组织。我们通过肌电图从缺乏肌梭感觉反馈的野生型和转基因小鼠的后肢肌肉活动中提取协同作用。肌梭缺陷小鼠经历了肌肉协同作用的时间结构（运动基元）的改变，导致行走时功能减弱。此外，时间和空间（电机模块）组件的协同作用受到严重影响时，引入外部扰动或当动物浸泡在水中。这些研究结果表明，感觉反馈组Ia/II肌梭调节运动功能正常和扰动行走。此外，当Ib组高尔基体腱器官反馈由于浮力增强而缺乏时，游泳的模块化组织几乎完全受损。
Key pointsLocomotion on land and in water requires the coordination of a great number of muscle activations and joint movements.Constant feedback about the position of own body parts in relation to the surrounding environment and the body itself (proprioception) is required to maintain stability and avoid failure.The central nervous system may follow a modular type of organization by controlling muscles in orchestrated groups (muscle synergies) rather than individually.We used this concept on genetically modified mice lacking muscle spindles, one of the two main classes of proprioceptors.We provide evidence that proprioceptive feedback is required by the central nervous system to accurately tune the modular organization of locomotion.AbstractFor exploiting terrestrial and aquatic locomotion, vertebrates must build their locomotor patterns based on an enormous amount of variables. The great number of muscles and joints, together with the constant need for sensory feedback information (e.g. proprioception), make the task of controlling movement a problem with overabundant degrees of freedom. It is widely accepted that the central nervous system may simplify the creation and control of movement by generating activation patterns common to muscle groups, rather than specific to individual muscles. These activation patterns, called muscle synergies, describe the modular organization of movement. We extracted synergies through electromyography from the hind limb muscle activities of wild‐type and genetically modified mice lacking sensory feedback from muscle spindles. Muscle spindle‐deficient mice underwent a modification of the temporal structure (motor primitives) of muscle synergies that resulted in diminished functionality during walking. In addition, both the temporal and spatial (motor modules) components of synergies were severely affected when external perturbations were introduced or when animals were immersed in water. These findings show that sensory feedback from group Ia/II muscle spindles regulates motor function in normal and perturbed walking. Moreover, when group Ib Golgi tendon organ feedback is lacking due to enhanced buoyancy, the modular organization of swimming is almost completely compromised.
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影响因子：
14.8
作者：
Zimmermann K;Hein A;Hager U;Kaczmarek JS;Turnquist BP;Clapham DE;Reeh PW
通讯作者：
Reeh PW
影响因子：
5.3
作者：
Akay, Turgay;Ludwar, Bjoern Ch.;Bueschges, Ansgar
通讯作者：
Bueschges, Ansgar
DOI：
--
发表时间：
2009
期刊：
--
影响因子：
--
作者：
D. Gates;J. Dingwell
通讯作者：
D. Gates;J. Dingwell
人体运动的非线性动力学：节奏听觉提示对局部动态稳定性的影响
影响因子：
4
作者：
P. Terrier;O. Deriaz
通讯作者：
O. Deriaz
肌梭源性神经营养素 3 调节肌肉感觉神经元和运动神经元之间的突触连接
影响因子：
5.3
作者：
Hsiao;W. Tourtellotte;E. Frank
通讯作者：
E. Frank