Time and technology will tell: the pathophysiologic basis of neurohormonal modulation in heart failure.
Time and technology will tell: the pathophysiologic basis of neurohormonal modulation in heart failure.
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DOI：
10.1016/j.hfc.2014.07.002
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发表时间：
2014-10
影响因子：
3.4
通讯作者：
Jensen BC
中科院分区：
文献类型：
--
作者：
Reed BN;Street SE;Jensen BC
Healers have been treating heart failure (HF) for millennia, but the central role of neurohormonal abnormalities in its pathogenesis and management was discovered only recently. 1 HF previously was understood almost entirely as the result of structural and functional abnormalities of the heart. In the eighteenth century, anatomists described gross enlargement of failing hearts removed at autopsy, and concluded rightly that hypertrophy was central to the pathobiology of HF. Technological advances in the early twentieth century permitted evaluation of the beating heart, and the field of cardiac physiology evolved. As a result, HF came to be conceived in mechanical terms: the fundamental insult in the failing heart was impaired contractility, and this abnormality was either exacerbated or alleviated by alterations in load. Structure and function reconciled well in animal physiology laboratories, because the hypertrophied and failing heart both resulted from and led to altered loading conditions.The essential role of neurohormonal disturbances in human HF was recognized first in the 1970s and brought to prominence in the 1980s and 1990s. 2 In this conception of HF, circulating substances synthesized in the heart, kidneys, adrenal glands, and pituitary glands engendered the characteristic anatomic and physiologic abnormalities described by earlier researchers. HF was no longer simply a disease of the heart.
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影响因子：
64.5
作者：
Anand P;Brown JD;Lin CY;Qi J;Zhang R;Artero PC;Alaiti MA;Bullard J;Alazem K;Margulies KB;Cappola TP;Lemieux M;Plutzky J;Bradner JE;Haldar SM
通讯作者：
Haldar SM
影响因子：
37.8
作者：
Devereux, RB;Dahlöf, B;Wachtell, K
通讯作者：
Wachtell, K
DOI：
10.1016/s0735-1097(03)00765-4
发表时间：
2003-08-20
影响因子：
24
作者：
Domanski, M;Norman, J;Peyster, E
通讯作者：
Peyster, E
影响因子：
4.8
作者：
Felker, GM;O'Connor, CM
通讯作者：
O'Connor, CM
影响因子：
37.8
作者：
Akhter, SA;Eckhart, AD;Koch, WJ
通讯作者：
Koch, WJ