Epigenomics and the microbiota.
Epigenomics and the microbiota.
复制标题
表观基因组学和微生物群。
DOI：
10.1177/0192623314553805
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发表时间：
2015-01
影响因子：
1.5
通讯作者：
Alenghat T
中科院分区：
文献类型：
--
作者：
Alenghat T
哺乳动物胃肠道是数万亿肠道微生物的家园，这些微生物共同构成肠道微生物群。这些微生物是调节体内平衡的重要环境因素，微生物群组成的改变与几种疾病有关，包括炎症性肠病（IBD），糖尿病和癌症。新的研究开始揭示可能调节这种与微生物群关系的表观基因组途径。表观基因组修饰改变了染色质的结构，因此改变了细胞的转录程序。这些修饰通过各种修饰和去修饰酶的动态活性来维持，这些酶的活性可以受到代谢物和其他环境线索的影响。组蛋白去乙酰化酶（HDAC）是一类受内源性和外源性因素调控的表观基因组修饰酶，最近的研究表明宿主HDAC的表达对于调节肠道微生物群和哺乳动物宿主细胞之间的通信是重要的。
The mammalian gastrointestinal tract is home to trillions of commensal microorganisms that collectively make up the intestinal microbiota. These microbes are important environmental factors that regulate homeostasis and alterations in the composition of the microbiota have been associated with several diseases, including inflammatory bowel disease (IBD), diabetes, and cancer. New research is beginning to uncover epigenomic pathways that may regulate this relationship with the microbiota. Epigenomic modifications alter the structure of the chromatin and therefore alter the transcriptional program of a cell. These modifications are maintained by the dynamic activity of various modifying and demodifying enzymes, the activities of which can be influenced by metabolites and other environmental cues. Histone deacetylases (HDACs) are a class of epigenomic-modifying enzymes that are regulated by both endogenous and exogenous factors and recent studies have suggested that host HDAC expression is important for regulating communication between the intestinal microbiota and mammalian host cells.
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影响因子：
56.9
作者：
Choudhary, Chunaram;Kumar, Chanchal;Mann, Matthias
通讯作者：
Mann, Matthias
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
64.8
作者：
Alenghat, Theresa;Osborne, Lisa C.;Saenz, Steven A.;Kobuley, Dmytro;Ziegler, Carly G. K.;Mullican, Shannon E.;Choi, Inchan;Grunberg, Stephanie;Sinha, Rohini;Wynosky-Dolfi, Meghan;Snyder, Annelise;Giacomin, Paul R.;Joyce, Karen L.;Hoang, Tram B.;Bewtra, Meenakshi;Brodsky, Igor E.;Sonnenberg, Gregory F.;Bushman, Frederic D.;Won, Kyoung-Jae;Lazar, Mitchell A.;Artis, David
通讯作者：
Artis, David
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
32.4
作者：
Ganal, Stephanie C.;Sanos, Stephanie L.;Diefenbach, Andreas
通讯作者：
Diefenbach, Andreas