The relevance of non-human primate and rodent malaria models for humans.
The relevance of non-human primate and rodent malaria models for humans.
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DOI：
10.1186/1475-2875-10-23
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发表时间：
2011-02-02
期刊：
影响因子：
3
通讯作者：
Duffy P
中科院分区：
文献类型：
--
作者：
Langhorne J;Buffet P;Galinski M;Good M;Harty J;Leroy D;Mota MM;Pasini E;Renia L;Riley E;Stins M;Duffy P
在2010年关于“疟疾：理解宿主-寄生虫相互作用的新方法”的基斯通研讨会上，应与会者的要求，召开了一个额外的科学会议，讨论疟疾研究中的动物模型。这是由于研究人员担心疟疾界对动物模型的使用和相关性的怀疑，特别是严重疟疾的啮齿动物模型，已经影响到使用动物模型的研究的资助决定和发表。几位发言者借此机会展示了啮齿动物模型和人类严重疾病的研究结果之间的相似之处以及不同点。不同实验模型中疟疾表现形式的多样性与人类疟疾疾病的广泛多样性相似，因此可能被视为一种优势。人类疟疾的许多关键特征可以在各种非人类灵长类动物模型中复制，而这些模型尚未得到充分利用。强调了动物模型在发现新的抗疟疾药物中的重要性。会议的主要结论是，实验研究和人体研究应该更紧密地联系在一起，以便相互了解，并且应该有更广泛的途径获得相关的临床材料。
At the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session to discuss animal models in malaria research was convened at the request of participants. This was prompted by the concern of investigators that skepticism in the malaria community about the use and relevance of animal models, particularly rodent models of severe malaria, has impacted on funding decisions and publication of research using animal models. Several speakers took the opportunity to demonstrate the similarities between findings in rodent models and human severe disease, as well as points of difference. The variety of malaria presentations in the different experimental models parallels the wide diversity of human malaria disease and, therefore, might be viewed as a strength. Many of the key features of human malaria can be replicated in a variety of nonhuman primate models, which are very under-utilized. The importance of animal models in the discovery of new anti-malarial drugs was emphasized. The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material.
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影响因子：
3
作者：
Cox-Singh J;Hiu J;Lucas SB;Divis PC;Zulkarnaen M;Chandran P;Wong KT;Adem P;Zaki SR;Singh B;Krishna S
通讯作者：
Krishna S
影响因子：
3
作者：
Daneshvar C;Davis TM;Cox-Singh J;Rafa'ee MZ;Zakaria SK;Divis PC;Singh B
通讯作者：
Singh B
DOI：
10.1164/rccm.200905-0786oc
发表时间：
2010-05-01
影响因子：
24.7
作者：
Van den Steen, Philippe E.;Geurts, Nathalie;Opdenakker, Ghislain
通讯作者：
Opdenakker, Ghislain
影响因子：
9.6
作者：
White, Nicholas J.;Turner, Gareth D. H.;Medana, Isabelle M.;Dondorp, Arjen M.;Day, Nicholas P. J.
通讯作者：
Day, Nicholas P. J.
影响因子：
3.1
作者：
Mota, MM;Jarra, W;Holder, AA
通讯作者：
Holder, AA